Hyperinsulinemia inversely correlates with fractional excretion of urate (FEUA), implicating URAT1-mediated urate reabsorption in hyperuricemia.
Phosphorylation of URAT1 at Thr408 by AKT and SGK1 kinases, induced by hyperinsulinemia and high salt intake, respectively, increases URAT1 activity and serum urate levels.
Genetic variants of SLC22A12 (notably rs147647315 and rs475688) modulate the impact of hyperinsulinemia on serum urate, highlighting gene-environment interactions.
These findings support personalized approaches to hyperuricemia treatment considering metabolic status and genetic background.
