Decompressive Craniectomy vs. Standard Craniotomy for Large Acute Epidural Hematoma with Tentorial Herniation: Insights from the PREDICT-AEDH Trial in China

Highlight

• The PREDICT-AEDH trial compared decompressive craniectomy with standard craniotomy in large acute epidural hematoma complicated by tentorial herniation.
• No significant difference was found in 6-month functional outcomes between treatment arms.
• Decompressive craniectomy increased the incidence of delayed intracranial hemorrhage compared to craniotomy.
• Current evidence does not support routine use of prophylactic decompressive craniectomy in this patient population.

Study Background