Clinical Updates – Page 8

Innovative Airway Scaffolds Demonstrate Safety and Efficacy in Reducing Hyperinflation in Severe Emphysema: Six-Month BREATHE Trial Results

By MedXY 09/19/2025

The BREATHE trial reveals that novel self-expanding nitinol airway scaffolds are safe, feasible, and effective in reducing lung hyperinflation and improving symptoms in severe emphysema patients at six months post-implantation.

Clinical Updates news Respiratory

Enhancing Home Non-Invasive Ventilation Outcomes Through Real-World Telemonitoring: Insights from the eVENT Randomised Study

By MedXY 09/19/2025

The eVENT study demonstrates that telemonitoring combined with remote support significantly improves arterial CO2 control and home NIV adherence compared to usual care, highlighting a promising approach to optimize chronic respiratory failure management.

Clinical Updates news Nursing & care Specialties

Efficacy of Germicidal UV Light in Reducing Acute Respiratory Infections in Long-Term Care Facilities for Older Adults: A Synthesis of Current Evidence

By MedXY 09/19/2025

This review discusses the randomized clinical trial evaluating germicidal UV light in long-term care facilities, highlighting its modest efficacy in reducing acute respiratory infections and its potential role in infection control for older adults.

Clinical Updates news OB/GYN & Women's Health

Optimizing Nifedipine GITS Dosing in Severe Preeclampsia: Daily 60 mg versus 30 mg BID – Evidence from a Randomized Controlled Trial

By MedXY 09/19/2025

This RCT compares nifedipine GITS 30 mg twice daily versus 60 mg once daily in severe preeclampsia, finding similar blood pressure control but fewer emergent treatments with twice-daily dosing, informing safer antihypertensive strategies in pregnancy.

Clinical Updates Critical Care news

Endothelial Glycocalyx Degradation in Sepsis: Insights from the CLOVERS Trial on Fluid Resuscitation Strategies and Mortality

By MedXY 09/19/2025

This article reviews findings from the CLOVERS trial analyzing endothelial glycocalyx degradation in sepsis, demonstrating its strong association with mortality but showing no impact of liberal versus restrictive fluid resuscitation strategies on glycocalyx integrity or survival outcomes.

Clinical Updates Diabetes & Endocrinology Internal Medicine news Specialties

Tirzepatide Influences Muscle Composition Favorably Amid Weight Loss in Type 2 Diabetes: Insights from SURPASS-3 MRI Substudy

By MedXY 09/19/2025

In type 2 diabetes patients, tirzepatide treatment led to significant reductions in muscle fat infiltration and adaptive decreases in muscle volume over 52 weeks, suggesting beneficial effects on muscle health concurrent with weight loss.

Clinical Updates news Oncology

Targeting the MEK/RTK Axis: A Promising Combination Therapy for KRAS-Mutant Non-Small Cell Lung Cancer

By MedXY 09/19/2025

Combining MEK inhibitor trametinib with pan-RTK inhibitor anlotinib shows high efficacy and manageable toxicity in treating advanced non-G12C KRAS-mutant NSCLC, overcoming adaptive resistance and offering improved clinical outcomes.

Cardiology Clinical Updates news Specialties

HEPA Air Purification Significantly Lowers Systolic Blood Pressure in Adults with Elevated BP Near Highways: Evidence from a Pragmatic Randomized Crossover Trial

By MedXY 09/19/2025

In-home HEPA air purifiers significantly reduce systolic blood pressure by 3.0 mm Hg in adults living near highways with elevated baseline BP, highlighting a practical intervention to mitigate cardiovascular risk from particulate pollution.

Clinical Updates Nephrology news

Lubiprostone Therapy in Chronic Kidney Disease: A Phase 2 Trial Reveals Mitochondrial Enhancement via Polyamine Modulation

By MedXY 09/19/2025

A phase 2 randomized trial in CKD patients shows lubiprostone preserves renal function by modulating gut microbiota polyamine pathways and improving mitochondrial health, independent of uremic toxin levels, offering a novel therapeutic avenue.

Clinical Updates Neurology news

Intravenous Antihypertensives Post-Endovascular Thrombectomy: Implications for Functional Recovery in Acute Ischemic Stroke

By MedXY 09/19/2025

Intravenous antihypertensive use within 24 hours after successful EVT in acute ischemic stroke associates with poorer functional outcomes and higher mortality, underscoring the need for cautious blood pressure management strategies post-thrombectomy.

Cardiology Clinical Updates

Equally Effective Dual Therapy Combinations for Hypertension in Indian Patients: Insights from a Landmark Randomized Trial

By MedXY 09/19/2025

This multicenter randomized trial in India shows that three dual antihypertensive combinations—amlodipine-perindopril, perindopril-indapamide, and amlodipine-indapamide—are equally effective and well-tolerated for 24-hour blood pressure control in South Asian adults.

Cardiology Clinical Updates news

Amiloride vs Spironolactone for Resistant Hypertension: A New Alternative Backed by Randomized Trial Evidence

By MedXY 09/19/2025

A recent randomized clinical trial demonstrates amiloride's noninferiority to spironolactone in lowering systolic blood pressure in resistant hypertension, offering a promising alternative therapy.

Cardiology Clinical Updates news

Opt-Out vs Opt-In Behavioral Framing in Remote Blood Pressure Monitoring: Insights from a Pragmatic Randomized Clinical Trial

By MedXY 09/19/2025

A randomized clinical trial evaluating behavioral economic framing for remote blood pressure monitoring found no significant difference in patient enrollment or retention between opt-out and opt-in approaches, though both improved blood pressure control compared to usual care.

Clinical Updates news Radiology Respiratory

Enhancing Hospitalist Care of Undifferentiated Dyspnea with Cardiopulmonary Point-of-Care Ultrasonography: Reducing Length of Stay and Costs

By MedXY 09/19/2025

Implementation of cardiopulmonary POCUS in hospitalist management of undifferentiated dyspnea significantly reduces hospital length of stay and costs, though adoption remains limited, highlighting the need for sustained training and support.

Clinical Updates news

Evaluating the Long-Term Effects of Cocoa Extract Supplementation on the Development of Hypertension: Insights from the COSMOS Trial

By MedXY 09/19/2025

The large-scale COSMOS trial reveals that while long-term cocoa extract supplementation does not reduce overall incident hypertension in older adults, it significantly lowers risk among individuals with normal baseline systolic blood pressure.

Clinical Updates Diabetes & Endocrinology news Specialties

Henagliflozin and Aging Biomarkers in Type 2 Diabetes: A Groundbreaking Multicenter Trial Reveals Promising Anti-Aging Effects

By MedXY 09/18/2025

A randomized placebo-controlled trial demonstrates that henagliflozin improves telomere length and multiple aging biomarkers in patients with type 2 diabetes, suggesting potential anti-aging benefits beyond glucose control.

Clinical Updates Hematology-Oncology news Specialties

Advancing Care in Older Adult T-Cell Leukemia/Lymphoma: Phase 2 Trial of Moga-CHOP-14 Combination Therapy

By MedXY 09/18/2025

A phase 2 study demonstrated that combining mogamulizumab with CHOP chemotherapy improves progression-free survival in older patients with adult T-cell leukemia/lymphoma, highlighting a promising first-line option.

Clinical Updates Diabetes & Endocrinology Neurology news Specialties

Fulmetibant’s Role in Diabetic Neuropathic Pain: Insights from the Phase 2a BRADiNP Study

By MedXY 09/18/2025

The BRADiNP study found that fulmetibant, a bradykinin-1 receptor antagonist, failed to significantly reduce diabetic neuropathic pain compared to placebo, despite favorable safety profiles, highlighting challenges in translating preclinical success to clinical efficacy.

Clinical Updates Diabetes & Endocrinology news Specialties

Lobeglitazone as an Effective and Safe Addition to Metformin and Sitagliptin Therapy in Type 2 Diabetes: Results from a 52-Week Multicentre Phase III Trial

By MedXY 09/18/2025

This phase III trial showed that adding lobeglitazone to metformin and sitagliptin significantly improves glycaemic control and insulin sensitivity with favorable safety over 52 weeks in Korean patients with type 2 diabetes inadequately controlled by dual therapy.

Cardiology Clinical Updates news Specialties

Repurposing Antihypertensive Drug Trazosin to Delay Vascular Aging: A Breakthrough in Atherosclerosis Management

By MedXY 09/18/2025

New research identifies transcription factor ATF3 as a key regulator of vascular smooth muscle cell aging and reveals low-dose trazosin, a commonly used antihypertensive, as a potential therapy to delay vascular aging and atherosclerosis progression via autophagy enhancement.