Highlights
– A 2025 systematic review and bayesian meta-analysis of 14 randomized trials (1,322 participants) found a 97.3% probability that shorter durations of prophylactic antibiotics (including none) are noninferior to 5–7 days for all-cause mortality after upper gastrointestinal bleeding in cirrhosis (RD 0.9%; 95% CrI −2.6 to 4.9).
– Shorter durations had a lower probability of noninferiority for early rebleeding (73.8%) and were associated with more trial-defined bacterial infections (RD 15.2%; 95% CrI 5.0 to 25.9).
