Early Uptake of Broad-Spectrum Antibiotic Prophylaxis in Pancreatoduodenectomy: Translating Trial Evidence into Practice
Posted inGeneral Surgery Infectious Diseases news

Early Uptake of Broad-Spectrum Antibiotic Prophylaxis in Pancreatoduodenectomy: Translating Trial Evidence into Practice

Following pivotal trial data demonstrating reduced infection and pancreatic fistula rates with piperacillin-tazobactam prophylaxis in pancreatoduodenectomy, adoption of broad-spectrum antibiotics increased significantly, particularly among patients with biliary stents, though racial disparities in use persisted.
Routine 5–7 Day Antibiotic Prophylaxis After Upper GI Bleeding in Cirrhosis: New Meta-analysis Questions the Mortality Benefit
Posted inGastroenterology Infectious Diseases news

Routine 5–7 Day Antibiotic Prophylaxis After Upper GI Bleeding in Cirrhosis: New Meta-analysis Questions the Mortality Benefit

A 2025 bayesian meta-analysis of 14 RCTs (n=1,322) found shorter or no antibiotic prophylaxis after upper GI bleeding in cirrhosis was highly likely to be noninferior for mortality, though it increased reported bacterial infections. Study limitations temper definitive practice change.