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Limited Direct Comparison of Me-Too Oncology Drugs with First-in-Class Agents: Clinical Implications and Regulatory Considerations
Posted innews Oncology Specialties

Limited Direct Comparison of Me-Too Oncology Drugs with First-in-Class Agents: Clinical Implications and Regulatory Considerations

Posted by By MedXY 07/31/2025
Analysis of FDA approvals from 2009–2020 reveals only 29% of next-in-class oncology drugs underwent head-to-head RCTs against originals, with just 22% showing survival benefits, highlighting a need for incentivized comparative trials.
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Sex-Specific Brain Volume Loss After Traumatic Brain Injury: Greater Impact in Older Women
Posted inNeurology news Specialties

Sex-Specific Brain Volume Loss After Traumatic Brain Injury: Greater Impact in Older Women

Posted by By MedXY 07/31/2025
A study from the Framingham Heart Study cohort reveals that traumatic brain injury (TBI) is linked to significant brain volume loss in older women but not men, highlighting sex-specific vulnerability to neurodegeneration post-TBI.
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High-Dose and Adjuvanted Flu Vaccines Offer Equivalent Protection for Older US Adults
Posted inCardiology Clinical Updates news Public Health Specialties

High-Dose and Adjuvanted Flu Vaccines Offer Equivalent Protection for Older US Adults

Posted by By MedXY 07/31/2025
A large US study finds adjuvanted and high-dose quadrivalent influenza vaccines provide comparable protection against lab-confirmed flu in seniors, supporting current immunization guidelines.
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FDA Approves First Vagus Nerve Stimulation Device for Rheumatoid Arthritis: New Horizons for Refractory Disease
Posted inClinical Updates news Rheumatology Specialties

FDA Approves First Vagus Nerve Stimulation Device for Rheumatoid Arthritis: New Horizons for Refractory Disease

Posted by By MedXY 07/31/2025
The FDA has approved the first vagus nerve stimulation device for moderate-to-severe rheumatoid arthritis unresponsive to biologic or synthetic DMARDs, offering a novel neuromodulatory approach to disease management.
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Balancing Stroke Prevention and Bleeding Risk: Timing of DOAC Restart After Serious Bleeding in Atrial Fibrillation
Posted inCardiology Clinical Updates news Specialties

Balancing Stroke Prevention and Bleeding Risk: Timing of DOAC Restart After Serious Bleeding in Atrial Fibrillation

Posted by By MedXY 07/31/2025
Early resumption of DOACs after serious bleeding in AF patients may lower stroke risk but significantly increases recurrent bleeding. Individualized decision-making and further research are recommended.
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Advances in Obesity and Diabetes Management: Highlights from ADA 2025
Posted inDiabetes & Endocrinology news Specialties

Advances in Obesity and Diabetes Management: Highlights from ADA 2025

Posted by By MedXY 07/31/2025
New weight-loss drug combinations, oral semaglutide cardiovascular outcomes, inhaled insulin for type 1 diabetes, and benefits of switching from diet drinks to water were key ADA 2025 findings.
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FDA Approves Lenacapavir: A Twice-Yearly Injectable PrEP Transforming HIV Prevention
Posted inHIV/AIDS Medical News news Public Health Specialties

FDA Approves Lenacapavir: A Twice-Yearly Injectable PrEP Transforming HIV Prevention

Posted by By MedXY 07/31/2025
Lenacapavir (Yeztugo) becomes the first FDA-approved, twice-yearly injectable PrEP, offering robust long-acting HIV prevention and addressing key adherence barriers.
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Fecal Microbiota Transplantation versus Vancomycin in Primary Clostridioides difficile Infection: A Noninferiority Randomized Trial
Posted inClinical Updates Infectious Diseases news Specialties

Fecal Microbiota Transplantation versus Vancomycin in Primary Clostridioides difficile Infection: A Noninferiority Randomized Trial

Posted by By MedXY 07/31/2025
FMT is noninferior to vancomycin for primary CDI, with similar cure rates and safety, suggesting it may be a viable first-line therapy.
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Walking More Than 100 Minutes Daily May Lower Risk of Chronic Low Back Pain
Posted inMedical News news Orthopedics Specialties

Walking More Than 100 Minutes Daily May Lower Risk of Chronic Low Back Pain

Posted by By MedXY 07/31/2025
A large prospective cohort study links daily walking of over 100 minutes to reduced risk of chronic low back pain, emphasizing walking volume over intensity as a preventive strategy.
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West Nile Virus: Clinical Burden, Diagnostic Challenges, and Prevention in the U.S.
Posted inClinical Updates Infectious Diseases news Public Health Specialties

West Nile Virus: Clinical Burden, Diagnostic Challenges, and Prevention in the U.S.

Posted by By MedXY 07/31/2025
West Nile virus is the leading mosquito-borne disease in the U.S., causing significant neuroinvasive morbidity and mortality, especially in older and immunocompromised individuals. With no approved treatments or vaccines, prevention and surveillance remain paramount.
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Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial
Posted inClinical Updates Neurology news Specialties

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

Posted by By MedXY 07/31/2025
The ANGEL-TNK trial found that intra-arterial tenecteplase after successful endovascular thrombectomy improved excellent neurological outcomes at 90 days without increasing bleeding or mortality, but secondary outcomes showed no significant benefit.
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Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial
Posted inClinical Updates news

Intra-arterial Tenecteplase After Thrombectomy for Acute Stroke: Interpreting the ANGEL-TNK Randomized Clinical Trial

Posted by By MedXY 07/31/2025
The ANGEL-TNK trial found that intra-arterial tenecteplase after successful endovascular thrombectomy improved excellent neurological outcomes at 90 days without increasing bleeding or mortality, but secondary outcomes showed no significant benefit.
Read More
Dual IL-17A/F Blockade and Increased Candidiasis Risk
Posted inClinical Updates Dermatology Infectious Diseases news Specialties

Dual IL-17A/F Blockade and Increased Candidiasis Risk

Posted by By MedXY 07/31/2025
Blocking both IL-17A and IL-17F impairs neutrophil migration, reducing antifungal defense and raising candidiasis risk in patients on bimekizumab, according to in vitro evidence.
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Inconsistent Bone Health Management in Older Women With Breast Cancer: Insights From the Age Gap Study
Posted inClinical Updates news Oncology Orthopedics Specialties

Inconsistent Bone Health Management in Older Women With Breast Cancer: Insights From the Age Gap Study

Posted by By MedXY 07/31/2025
Significant variation exists in bone health management for older women receiving endocrine therapy for breast cancer, highlighting the need for standardized care.
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Polymyalgia Rheumatica Not Associated with Increased Mortality: Insights from a 38-Year Norwegian Cohort Study
Posted inClinical Updates news Rheumatology Specialties

Polymyalgia Rheumatica Not Associated with Increased Mortality: Insights from a 38-Year Norwegian Cohort Study

Posted by By MedXY 07/31/2025
A 38-year prospective study in Southern Norway demonstrates that isolated polymyalgia rheumatica (PMR) does not increase all-cause mortality compared to matched population controls, with men showing even lower mortality risk.
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ED Intubation in Active Hemorrhage Linked to Increased Mortality: Insights from a Nationwide Cohort Study
Posted inClinical Updates news Oncology Specialties

ED Intubation in Active Hemorrhage Linked to Increased Mortality: Insights from a Nationwide Cohort Study

Posted by By MedXY 07/31/2025
Intubation in the emergency department for trauma patients with active hemorrhage is associated with higher mortality, more ICU admissions, and greater transfusion needs compared to intubation in the operating room.
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Veligrotug Emerges as a Promising Therapy for Thyroid Eye Disease: Insights from the THRIVE and THRIVE-2 Trials
Posted inClinical Updates Diabetes & Endocrinology news Ophthalmology Specialties

Veligrotug Emerges as a Promising Therapy for Thyroid Eye Disease: Insights from the THRIVE and THRIVE-2 Trials

Posted by By MedXY 07/31/2025
Veligrotug demonstrates robust efficacy and manageable safety in both active and chronic thyroid eye disease, positioning itself as a potential alternative to teprotumumab based on phase 3 THRIVE trial data.
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Sharp Rise in Advanced Alcohol-Related Liver Disease Despite Stable Drinking Rates: Changing Population Risks Highlighted by US Data
Posted inGastroenterology Medical News news Specialties

Sharp Rise in Advanced Alcohol-Related Liver Disease Despite Stable Drinking Rates: Changing Population Risks Highlighted by US Data

Posted by By MedXY 07/31/2025
A twofold rise in advanced liver fibrosis among US heavy drinkers over two decades is linked to increased metabolic syndrome, age, and socioeconomic risk, not higher alcohol intake.
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Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation
Posted inAnesthesiology Clinical Updates Critical Care news Pediatrics Specialties

Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation

Posted by By MedXY 07/31/2025
A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.
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Posted inFamily Medicine & Nutrition news Pediatrics Public Health Specialties

Sweetener Consumption and Genetic Predisposition: New Insights into Early Puberty Risk in Children

Posted by By Dr.Paul 07/31/2025
Sweetener intake, especially aspartame and sucralose, is linked to increased risk of early puberty in genetically predisposed children, with notable sex-specific differences
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  • Closed-Loop Insulin Delivery in Type 1 Diabetes During Pregnancy: Insights from the CIRCUIT Randomized Clinical Trial and Contemporary Evidence
  • Enhancing Postoperative Sexual Readiness in Urogynecologic Surgery: Insights from a Randomized Trial
  • Developing a Patient-Centered Counseling Tool for Resuming Sexual Activity After Pelvic Reconstructive Surgery: A Qualitative and Cognitive Interview Approach
  • Enhanced Healing in Periodontal Surgery: The Promise of Cyanoacrylate Adhesives in Free Gingival Graft Stabilization
  • Unraveling Chronic Rejection in Vascularized Composite Allotransplantation: Clinical Manifestations, Mechanisms, and Future Directions
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