Widespread Anticoagulation Has Lowered Stroke but Not Intracranial Bleeding in the Very Elderly: Insights from a Danish Nationwide AF Cohort (1999–2022)

Highlight

– Nationwide Danish data (1999–2022) including 243,938 new-onset AF patients show marked decreases in stroke risk across age groups coincident with broad uptake of oral anticoagulants (OACs).

– Five-year absolute improvement in stroke-free survival was greatest in ages 75–84 (+12.8%) and 65–74 (+10.1%), but only +3.5% in patients ≥85.