Posted innews
ほとんどの極低出生体重児は2歳前に再入院を必要とする — 新生児期の病態が病院滞在日数を大幅に増加させる
イングランドとウェールズの全国コホート研究によると、32週未満で生まれた乳児のうち、2歳までに1回以上の入院を経験した割合が2/3に達し、周産期の低出生体重と新生児期の病態（BPD、重度NEC、脳損傷）が総入院日数を大幅に増加させている。
Posted innews Pediatrics Public Health
Most Very Preterm Infants Require Hospital Readmission Before Age 2 — Neonatal Morbidities Strongly Increase Days Spent in Hospital
A national cohort study from England and Wales found two-thirds of infants born <32 weeks’ gestation had ≥1 hospital admission before age 2, with lower gestational age and neonatal morbidities (BPD, severe NEC, brain injury) substantially increasing total hospitalization days.
Posted innews Pediatrics
Wide International Variation in Survival and Morbidity for Infants Born at 22–23 Weeks: Implications for Care, Counseling, and Research
An international cohort of 5,019 infants born at 22–23 weeks shows large between‑network variation in survival and major morbidities, highlighting effects of practice, systems, and policy on outcomes and the need for unified data-driven strategies.
Posted innews Pediatrics Psychiatry
Uncertain Evidence for Youth Suicide Interventions: DBT Shows Promise While Medications and Neurotherapies Remain Largely Unstudied
A 2025 systematic review of 65 studies (14,534 youths) finds moderate evidence for dialectical behavior therapy reducing suicidal ideation; other psychosocial interventions have low or insufficient evidence and pharmacologic/neurotherapeutic approaches are largely untested.
Breast Cancer Index in Premenopausal HR+ Disease: Prognostic Confirmed, Predictive Role for OFS-Intensification Context-Dependent
Two large prospective‑retrospective analyses confirm BCI as a robust prognostic biomarker in premenopausal HR+ breast cancer; its HOXB13/IL17BR (H/I) component predicted benefit from adding ovarian function suppression versus tamoxifen alone but did not clearly predict superiority of exemestane+OFS over tamoxifen+OFS.
Posted inCardiology Neurology news
Beyond the Lesion: Long-Term Cardiovascular, Neurologic, Psychiatric, and Endocrine Risks After Traumatic Spinal Cord Injury
A large retrospective cohort study shows traumatic spinal cord injury (TSCI) is associated with increased long-term cardiovascular, neurologic, psychiatric, and endocrine morbidity and higher mortality, even in previously healthy adults.
Early‑Onset Colorectal Cancer: Parsing an Epidemiologic Artifact from True Molecular Signals — Toward a Clinically Actionable Molecular Taxonomy
Integrated analysis shows a 2013 NEN classification change inflated EOCRC counts in the youngest adults, while independent molecular studies reveal distinct hypermutated and non‑hypermutated EOCRC subtypes with higher MSI/TMB and pathway-specific differences across populations. Implications for diagnosis, surveillance, and precision therapy are discussed.
Posted inFamily Medicine & Nutrition news
Plate for the Planet: How the “Planetary Health Diet” Can Extend Your Life
In a world grappling with dual crises—rising chronic disease rates and accelerating climate change—a team…
Enhancing Access to Mifepristone via Community Pharmacies: Evidence from Routine Prescription Regulation in British Columbia, Canada
This review synthesizes data on mifepristone availability at community pharmacies in BC, highlighting geographic coverage, dispensing gaps, and disparities influencing timely access to medication abortion.
Posted inClinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news OB/GYN & Women's Health
Planetary Health Diet and Cardiometabolic Risk Reduction in Women with Gestational Diabetes: An Evidence-Based Review
This review synthesizes evidence linking adherence to the Planetary Health Diet with reduced risks of myocardial infarction, type 2 diabetes, and improved weight management in women post-gestational diabetes, highlighting BMI's mediating role.
Posted inCritical Care news Pediatrics
Epinephrine Timing and Dosing in Pediatric In‑Hospital Cardiac Arrest: Mixed Signals — improved ROSC but unclear survival benefit
Recent multicenter studies show earlier and more frequent epinephrine in pediatric in‑hospital cardiac arrest increases ROSC and shortens CPR, but does not consistently improve survival to discharge or favorable neurologic outcome. Evidence supports rapid epinephrine for hemodynamics and ROSC; survival effects remain uncertain.
Offering Multiple Appropriate Alternatives Increases Primary Care Physicians’ Adoption of Recommended Care: A Randomized Trial
A randomized trial of 402 US primary care physicians found that presenting two or more appropriate treatment alternatives (vs one) increased clinicians’ likelihood of changing from a status quo plan to an evidence‑based alternative, especially for opioid prescribing; adding options beyond two provided no further benefit.
Posted inCritical Care news Pediatrics
Pediatric In‑Hospital Cardiac Arrest: Why Adult Resuscitation Lessons Don’t Fully Translate — Airway, Epinephrine, and the Limits of Training
Recent multicenter studies show declining intra‑arrest intubation, no clear harm from intubation after time‑dependent matching, unclear benefit of epinephrine before defibrillation, and no survival gain from intensive point‑of‑care CPR training—highlighting pediatric physiology and knowledge gaps.
Posted inGastroenterology news Pediatrics
Condition-Specific Growth Charts and a New Medical Therapy for Alagille Syndrome: Implications for Growth Assessment and Symptom Control
Two recent multicenter studies provide condition-specific growth charts for children with Alagille syndrome and show that ileal bile acid transporter inhibition with odevixibat reduces pruritus and serum bile acids — reshaping growth assessment and medical management.
Posted inCritical Care Emergency Medicine Neurology news
Prehospital Postintubation Hypotension Strongly Linked to 30‑Day Mortality After Severe Traumatic Brain Injury — Especially in Isolated TBI
A multicenter cohort study of 555 patients with severe TBI who underwent prehospital rapid sequence induction found postintubation hypotension (SBP <90 mmHg within 10 minutes) in 19.1%, which was associated with higher 30‑day mortality (AOR 1.70). The association was markedly stronger in isolated TBI (AOR 13.55).
Posted inDiabetes & Endocrinology news Public Health
Early-Life Famine Exposure in Chinese Immigrants Strongly Linked to Later Diabetes and Hypertension — But Not Cardiovascular Hospitalization
A large Ontario cohort study links early-life exposure to the Great Chinese Famine with higher adult risks of type 2 diabetes and hypertension among Chinese immigrants, while cardiovascular hospitalization was not increased; methodological caveats underline need for age-balanced research.
Posted inClinical Updates Gastroenterology news Oncology
Proton Pump Inhibitor Use and Survival Outcomes in Newly Diagnosed Glioblastoma: An Evidence-Based Review
Proton pump inhibitor use, particularly potent ALDH1A1-activating PPIs, is associated with worse survival in newly diagnosed glioblastoma, highlighting the need for cautious use and further mechanistic research.
Posted inClinical Updates news Pediatrics Respiratory
Reevaluating the Link Between Household Air Pollution from Biomass Cooking and Severe Pneumonia in Infants: A Comprehensive Evidence Synthesis
Recent high-quality studies challenge the presumed association between household air pollution from biomass cooking and severe infant pneumonia, highlighting inconsistent exposure-response relationships for PM2.5 and CO.
Posted inCardiology news Psychiatry
Tailored Digital Emotion Regulation Improves Mental Health in Adults With Congenital Heart Disease: Results of a National Randomized Trial
A 3‑arm randomized trial in 524 adults with congenital heart disease found a 4‑week tailored digital emotion‑regulation program produced moderate improvements in emotion regulation and multiple psychosocial outcomes versus usual care; a general program showed delayed, smaller benefits.
Atezolizumab–Bevacizumab Provides the Best Balance of Survival and Quality of Life in First‑Line Advanced Hepatocellular Carcinoma
A Bayesian network meta-analysis integrating health‑related quality of life and overall survival across first‑line trials in advanced hepatocellular carcinoma shows atezolizumab plus bevacizumab provides the most favorable combined patient‑centered outcome profile.