news – Page 2 – Medxy AI

Molecular Interplay of TREM2 and ApoE Variants in Alzheimer’s Disease: Structural Insights and Therapeutic Implications

By MedXY 10/21/2025

This article elucidates how TREM2-apoE3 interactions are structurally altered by Alzheimer's-associated TREM2 R47H and apoE4 variants, revealing potential mechanisms that contribute to disease risk and informing therapeutic targeting strategies.

Neurology news Specialties

APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients

By MedXY 10/21/2025

The APOE ε4 allele significantly reduces survival in Parkinson's disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.

Cardiology Neurology news Specialties

Obicetrapib’s Role in Modulating Alzheimer’s Disease Biomarkers in Patients with Cardiovascular Disease: A Landmark Clinical Study

By MedXY 10/21/2025

Obicetrapib, a CETP inhibitor, lowers Alzheimer’s biomarkers like p-tau217 in ASCVD patients, especially ApoE4 carriers, suggesting a potential preventive strategy for high-risk individuals.

Neurology news

Pregnancy Hypertension and Elevated p-tau217: A Midlife Indicator of Alzheimer’s Disease Risk in Women

By MedXY 10/21/2025

Pregnancy hypertension is independently associated with higher serum p-tau217 levels in midlife women, suggesting a link to preclinical Alzheimer’s disease pathology and potential for early screening and intervention.

Cardiology Family Medicine & Nutrition news Specialties

Dietary Patterns and Intracranial Atherosclerosis Risk in Elderly Patients With Hypertension or Myocardial Infarction: An Evidence-Based Review

By MedXY 10/21/2025

Healthy dietary patterns may reduce intracranial atherosclerosis severity in older adults with hypertension or prior myocardial infarction, suggesting diet's conditional protective role in vascular brain disease.

Neurology news Specialties

Rapamycin for Alzheimer’s Prevention in APOE4 Carriers: Restoring Brain Metabolism and Vascular Health

By MedXY 10/21/2025

Rapamycin shows promise in preventing Alzheimer's disease in APOE4 carriers by improving brain mitochondrial function, synaptic activity, and vascular health, highlighting a potential genotype-targeted early intervention for this high-risk population.

Family Medicine & Nutrition Neurology news Specialties

APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo

By MedXY 10/21/2025

This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African populations.

Family Medicine & Nutrition Neurology news Specialties

Lifetime Walking Intensity and Duration Reduce Amyloid-β Accumulation in Alzheimer’s Disease: Insights from a Korean Longitudinal Cohort

By MedXY 10/20/2025

A 4-year longitudinal study reveals that long-duration, high-intensity lifetime walking is associated with reduced amyloid-β accumulation in older adults, suggesting a neuroprotective effect when initiated early in life.

Neurology news Pathology & Lab Medicine Public Health

Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study

By MedXY 10/20/2025

Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.

Critical Care Emergency Medicine news Public Health Specialties

Empowering Older Adults in Acute Care: Insights on Shared Decision Making for Treatment Escalation Planning

By MedXY 10/20/2025

This qualitative UK study explores older patients' perspectives on shared decision making for treatment escalation during acute hospital deterioration, highlighting the need for patient autonomy, education, and adaptable clinical approaches.

Internal Medicine Neurology news

Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults

By MedXY 10/20/2025

This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.

Internal Medicine news Public Health

Optimizing Healthy Ageing: The Impact of Physical Activity and Sedentary Behavior on Intrinsic Capacity in Older Adults

By MedXY 10/20/2025

This prospective Spanish cohort study reveals that moderate-to-vigorous physical activity enhances intrinsic capacity in older adults, while sedentary behavior impairs it, underscoring the role of active lifestyles in promoting healthy ageing.

Neurology news Public Health

Evolving Landscape of Modifiable Dementia Risk Factors in Australia: Socioeconomic and Sex Disparities Over 15 Years

By MedXY 10/20/2025

This analysis reveals stable dementia risk fractions despite changing risk profiles over 15 years in Australia, highlighting greater modifiable risk among low-income groups and males, with depression emerging as a leading factor in mid-life, especially in women and disadvantaged populations.

Internal Medicine news Public Health

Global Mortality Trends 1990-2023: Insights from the GBD 2023 Study on Causes of Death

By MedXY 10/20/2025

The GBD 2023 Study integrates data from 204 countries to reveal shifting global mortality patterns, emphasizing the impact of COVID-19, declining vaccine-preventable deaths, and rising non-communicable diseases, highlighting critical areas for targeted public health action.

Gastroenterology news Pediatrics

Pharmacological Treatments for Pediatric Functional Constipation: A Comprehensive Systematic Review and Meta-Analysis

By MedXY 10/20/2025

This systematic review and meta-analysis evaluates the efficacy and safety of pharmacological therapies for functional constipation in children, identifying polyethylene glycol as the preferred first-line treatment based on moderate-certainty evidence.

Diabetes & Endocrinology news Public Health

Leveraging the Planetary Health Diet to Reduce Type 2 Diabetes Risk and Environmental Impact: Insights from the EPIC-Norfolk Study

By MedXY 10/20/2025

Higher adherence to the planetary health diet is linked with a 32% reduced risk of type 2 diabetes and significantly lower greenhouse gas emissions, supporting its role in preventing diabetes and promoting sustainability.

Cardiology news Oncology

Impacts of Plant-Based Diets on Multimorbidity Risk in Cancer and Cardiometabolic Diseases Across Age Groups

By MedXY 10/20/2025

This analysis of EPIC and UK Biobank cohorts reveals that healthy plant-based diets reduce multimorbidity risk of cancer and cardiometabolic diseases, especially in middle-aged adults, underscoring diet's role in chronic disease prevention and management.

Internal Medicine news Public Health

Extending the Hospital Frailty Risk Score to All Adults: Implications for Hospital Stay, Mortality, and Costs in England

By MedXY 10/20/2025

The Hospital Frailty Risk Score (HFRS) predicts length of stay, mortality, and costs across all adult age groups in England, with stronger effects in older adults, supporting broader clinical use beyond the elderly.

Neurology news Public Health

Age-Dependent Impact of Vascular Risk Factors on Acute Stroke: Insights from the INTERSTROKE Study

By MedXY 10/20/2025

The INTERSTROKE study reveals how age modifies the relationship between vascular risk factors and acute stroke, highlighting age-specific prevention priorities to reduce stroke burden globally.

Clinical Updates news

Enlarged Perivascular Spaces as Early Neurovascular Biomarkers in Alzheimer Disease: Integrating Serum and MRI Findings from Multicultural Cohorts

By MedXY 10/20/2025

Enlarged perivascular spaces (EPVS) correlate with serum biomarkers of neuroinflammation and amyloid pathology and associate with cognitive impairment, supporting their role as early MRI markers for Alzheimer disease (AD) vascular contributions and pathology.