VO2 Recovery Time as a Novel Cardiac Performance Biomarker: Insights from the SEQUOIA-HCM Trial

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1. VO2T12.5%, the time for oxygen uptake to decrease by 12.5% post-exercise, is a novel, easily derivable measure reflecting cardiac performance during exercise.

2. Prolonged VO2T12.5% correlates with adverse hemodynamics and predicts higher risks of heart failure hospitalization and mortality in patients with dyspnea on exertion.

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