risk stratification

Septal Curvature Ratio on CTPA Identifies Normotensive PE Patients at High Risk of Early Deterioration

By MedXY 11/06/2025

A multicentre prospective study shows the ventricular septum curvature ratio on CTPA strongly predicts 30‑day clinical deterioration in normotensive acute pulmonary embolism, outperforming conventional single metrics and offering potential for early risk stratification.

news Oncology Urology

Rethinking Gleason Grade Group 1 Prostate Cancer: Insights from a Large-Scale Cohort Study

By MedXY 10/27/2025

This study highlights the heterogeneity of GG1 prostate cancer and its implications for classification and management strategies.

Dermatology Hematology-Oncology news

T-Cell Receptor Clonotypes as Prognostic Markers in Cutaneous T-Cell Lymphoma: Insights from Next-Generation Sequencing

By MedXY 10/24/2025

This study identifies specific T-cell receptor clonotypes associated with aggressive subtypes and poorer survival in mycosis fungoides and Sézary syndrome, supporting TCR sequencing as a tool for refined risk stratification in cutaneous T-cell lymphoma.

Dermatology General Surgery Oncology

Refining Sentinel Lymph Node Biopsy Decisions in Melanoma: Insights from the MERLIN_001 Gene Expression Profiling Study

By MedXY 10/24/2025

The MERLIN_001 study validates a combined clinicopathological and gene expression profile test that accurately predicts sentinel lymph node metastasis risk in patients with cutaneous melanoma, potentially guiding safer, more personalized surgical decisions.

Cardiology Specialties

Enhanced GRACE 3.0 Score for Personalized Management of Non-ST-Elevation Acute Coronary Syndrome: Insights from a Multinational Validation Study

By MedXY 10/19/2025

The updated GRACE 3.0 scoring system improves mortality prediction and personalizes early invasive treatment decisions in non-ST-elevation acute coronary syndrome across ten countries, demonstrating excellent validation and clinical utility.

AI Cardiology Specialties

Harnessing Artificial Intelligence for Enhanced Prediction of Complete Heart Block Risk via Electrocardiography

By MedXY 09/27/2025

AIRE-CHB, a novel AI-enhanced ECG model, significantly improves prediction of incident complete heart block, outperforming traditional bifascicular block assessment and offering promising clinical utility in risk stratification and management.

Emergency Medicine Infectious Diseases news Pediatrics Public Health Specialties

Enhancing Early Risk Stratification of Severe Childhood Febrile Illness in Rural Asia Using sTREM1 Biomarker

By MedXY 08/30/2025

A multicountry study across Asia demonstrates soluble TREM1's superior accuracy over traditional clinical signs in predicting severe febrile illness in children, potentially transforming triage in resource-limited settings.

AI Cardiology Specialties

Advancing Acute Coronary Syndrome Care: ECG-Based Machine Learning Enhances Risk Stratification

By MedXY 08/16/2025

A prospective study shows that machine learning models trained on 12-lead ECG features outperform HEART score in predicting mortality among chest pain patients, improving risk-based care precision.

Clinical Updates news Oncology Specialties

Beyond Negative: Quantitative Fecal Hemoglobin Levels Refine Colorectal Cancer Risk Stratification in FIT-based Screening

By MedXY 08/06/2025

New meta-analysis reveals a strong dose-response relationship between fecal hemoglobin concentration and colorectal neoplasia risk, even among FIT-negative individuals, supporting personalized screening intervals.