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Clozapine Works Beyond Schizophrenia: Nationwide Evidence for Transdiagnostic Effectiveness and Safety
Posted innews Psychiatry

Clozapine Works Beyond Schizophrenia: Nationwide Evidence for Transdiagnostic Effectiveness and Safety

Posted by MedXY By MedXY 12/01/2025
Large Finnish and Swedish registry cohorts show clozapine is associated with lower psychiatric hospitalisation across schizophrenia-spectrum, bipolar disorder and severe depression without increased overall mortality or hospitalisation.
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Prior Osteotomy Lowers Implant Survival and Raises TKA Complexity — but Early Pain and Function Are Similar: Results from 189,932 Dutch Arthroplasties
Posted innews Orthopedics

Prior Osteotomy Lowers Implant Survival and Raises TKA Complexity — but Early Pain and Function Are Similar: Results from 189,932 Dutch Arthroplasties

Posted by MedXY By MedXY 11/02/2025
A large Dutch registry analysis shows total knee arthroplasty (TKA) after prior knee osteotomy carries a modestly higher revision risk and more frequent use of stems/augments, while short-term pain and function are comparable to primary TKA.
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  • Observation Reduces CT Use in Pediatric Blunt Abdominal Trauma Without Missing Critical Injuries
  • Digital Mental Health Interventions Show Promise for Black and Female Health Care Workers
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