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Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial
Posted innews Psychiatry

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression: The EPISODE Randomized Clinical Trial

Posted by MedXY By MedXY 05/19/2026
Psilocybin-assisted psychotherapy showed promising but inconclusive antidepressant effects in treatment-resistant depression, with notable acute adverse events and safety concerns.
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Brief Psychological Intervention for Personality Disorder Shows No Benefit: Insights from the SPS Trial
Posted innews Psychiatry

Brief Psychological Intervention for Personality Disorder Shows No Benefit: Insights from the SPS Trial

Posted by MedXY By MedXY 02/24/2026
A multicentre RCT in England demonstrates that a 10-session brief psychological intervention offers no significant improvement in social functioning or cost-effectiveness for individuals with probable personality disorder, reinforcing the need for sustained, long-term therapeutic programs.
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Behavioral Activation Reduces Perinatal Suicide Ideation: Insights from the SUMMIT Trial
Posted innews OB/GYN & Women's Health Psychiatry

Behavioral Activation Reduces Perinatal Suicide Ideation: Insights from the SUMMIT Trial

Posted by MedXY By MedXY 10/27/2025
A secondary analysis of the SUMMIT trial shows that brief behavioral activation therapy significantly reduces suicide ideation in perinatal women, regardless of clinician type or treatment modality, highlighting a scalable approach for suicide prevention in this vulnerable population.
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Comparative Effectiveness of PTSD Treatments in Primary Care: Insights from a Pragmatic Randomized Trial
Posted inFamily Medicine & Nutrition news Psychiatry

Comparative Effectiveness of PTSD Treatments in Primary Care: Insights from a Pragmatic Randomized Trial

Posted by MedXY By MedXY 10/15/2025
A pragmatic trial comparing SSRIs and written exposure therapy in primary care PTSD treatment found similar effectiveness initially; switching to SNRI was superior to WET augmentation for SSRI nonresponders.
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