prediabetes – Medxy AI

Prediabetes Remission Without Weight Loss: Rethinking Targets to Prevent Type 2 Diabetes

By MedXY 11/12/2025

A post hoc analysis of PLIS and replication in the DPP show that achieving prediabetes remission—normalization of glucose—can prevent type 2 diabetes even without net weight loss, via improved insulin sensitivity, β‑cell function and favorable adipose redistribution.

Diabetes & Endocrinology Internal Medicine news

Rethinking Prediabetes: Controlling Blood Sugar Without Losing Weight Shows Promise

By MedXY 11/01/2025

A groundbreaking study reveals that lifestyle changes improving fat distribution and insulin function can reverse prediabetes without weight loss, significantly cutting type 2 diabetes risk.

AI Clinical Updates Diabetes & Endocrinology news

Evaluating AI-Led vs Human-Led Lifestyle Interventions in Prediabetes: Evidence from a Randomized Clinical Trial of the Diabetes Prevention Program

By MedXY 10/29/2025

This review examines the first phase 3 randomized trial demonstrating that an AI-powered Diabetes Prevention Program lifestyle intervention is noninferior to human coaching in improving weight loss, HbA1c, and physical activity among adults with prediabetes and overweight or obesity.

Diabetes & Endocrinology Psychiatry Specialties

Semaglutide for Metabolic Health in Schizophrenia: Insights from the HISTORI RCT

By MedXY 10/22/2025

The HISTORI trial demonstrates that semaglutide significantly improves glycemic control, reduces weight, and enhances physical quality of life in schizophrenia patients treated with second-generation antipsychotics, without worsening psychiatric symptoms.

Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Hydroxytyrosol Supplementation Enhances Antioxidant and Anti-Inflammatory Status in Overweight Prediabetic Adults: Insights from a Randomized Controlled Trial

By MedXY 09/17/2025

A 16-week randomized trial demonstrates that daily hydroxytyrosol supplementation significantly reduces oxidative stress and inflammatory markers in overweight individuals with prediabetes, highlighting its potential in preventing aging-related diseases.

Clinical Updates Diabetes & Endocrinology Family Medicine & Nutrition news Specialties

Enhancing Metformin Efficacy and Tolerability in Prediabetes Through a Fermentable Carbohydrate-Rich Diet

By MedXY 09/17/2025

A fermentable carbohydrate-enriched diet combined with metformin improves postprandial glycaemia, enhances GLP-1 secretion, and positively alters gut microbiota in prediabetic individuals, offering a personalized nutrition-pharmacology strategy for diabetes prevention.

Diabetes & Endocrinology news Specialties

Synergistic Effects of Metformin and Moderate FODMAP Diet in Improving Postprandial Glycemia and Gut Health in Prediabetes

By MedXY 08/17/2025

Combining metformin with a moderate FODMAP diet improves postprandial glucose control, enhances GLP-1 secretion, increases butyrate-producing gut bacteria, and reduces inflammation without worsening gastrointestinal side effects in prediabetic patients.