microbiome – Medxy AI

Antibiotic Exposure Linked to Shorter Biologic Survival in Psoriasis: A Large French Cohort Suggests a Dose–Response Relationship

By MedXY 11/17/2025

A nationwide retrospective cohort (36,129 patients) found antibiotic use before or during biologic treatment for psoriasis was associated with higher risk of discontinuation or switch; multiple dispensations carried larger risk, suggesting antibiotic-associated dysbiosis may reduce biologic persistence.

Gastroenterology Neurology news

Microbiota, 3‑Hydroxyanthranilic Acid and Dopaminergic Signalling: A New Pathway Linking Obesity to Attention Deficits

By MedXY 11/07/2025

A multi-cohort human study with mouse and Drosophila validation implicates gut microbes and the tryptophan metabolite 3‑hydroxyanthranilic acid in modulating attention in obesity, suggesting microbiota-directed interventions could improve cognitive function.

Gastroenterology Infectious Diseases news

Evaluating the Necessity of Live Microbes in Fecal Microbiota Transplantation for C. difficile Recurrence: Insights from a Non-Inferiority Trial

By MedXY 10/18/2025

This study investigates whether sterile lyophilised fecal filtrate is as effective as traditional donor stool in preventing recurrent C. difficile infection, highlighting the importance of live microbes in treatment efficacy.

Clinical Updates Gastroenterology news

Decoding the Role of Reflux Secondary Bile Acids in Barrett’s Esophagus: Microbiome and Transcriptome Insights

By MedXY 09/25/2025

This study reveals that elevated reflux secondary bile acids in Barrett's esophagus influence the esophageal microbiome and gene expression, highlighting potential mechanisms underpinning progression to esophageal adenocarcinoma.

Family Medicine & Nutrition news Specialties

The Gut’s Sixth Sense: How Your Microbiome Quietly Controls Appetite

By MedXY 08/31/2025

Recent research unveils a 'neurobiotic sense' in the gut that detects bacterial molecules and regulates feeding through the gut-brain axis, reshaping our understanding of appetite control.

Family Medicine & Nutrition Neurology Specialties

Exploring the Gut Microbiota-Insomnia Connection: Evidence and Controversies

By MedXY 08/18/2025

A recent Mendelian randomization study suggests bidirectional causal links between specific gut bacteria and insomnia, highlighting potential microbiome-based interventions, though causality remains debated among experts.

Clinical Updates Family Medicine & Nutrition Internal Medicine news Specialties

Metformin and ‘Anti‑Aging’: Promising Mechanisms but Mixed Clinical Evidence — What Recent Trials Tell Us

By MedXY 08/09/2025

Recent randomized and mechanistic studies provide a nuanced view: metformin shows plausible anti‑aging mechanisms and microbiome‑linked cognitive associations, but randomized trials report no clear anti‑cancer or anti‑senescence effects in humans to date.

Gastroenterology news Psychiatry

Your Gut, Your Mood: How the ‘Second Brain’ Can Beat the Blues

By MedXY 08/04/2025

Explore how the gut, often called the 'second brain,' influences mood and mental health, and learn ways to nurture this connection for better emotional well-being.

Gastroenterology news

Gut Feeling: The Surprising Link Between Your Stomach and Your Mood

By MedXY 07/25/2025

Emerging science reveals how your gut and brain communicate, shaping not only digestion but also emotions and mental health.