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MDM2 degrader

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KT-253: A Novel MDM2 Degrader Targeting Malignant Stem Cells in Myelofibrosis
Posted inHematology-Oncology news

KT-253: A Novel MDM2 Degrader Targeting Malignant Stem Cells in Myelofibrosis

Posted by By MedXY 10/14/2026
KT-253, a selective MDM2 protein degrader, shows potent elimination of malignant myelofibrosis stem/progenitor cells by enhancing p53 pathway activation, outperforming current MDM2 inhibitors and offering a promising therapeutic advance.
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