immune dysregulation

Malignancy Risk after Ophthalmic Herpes Infection within a Diverse United States Cohort: Clinical Insights and Implications

By MedXY 08/25/2026

Ophthalmic herpes infections generally do not increase overall malignancy risk, but herpes zoster ophthalmicus (HZO) elevates cancer risk in patients with immune dysregulation, underscoring the need for tailored oncologic vigilance.

Gastroenterology news Pediatrics

Neutralising Autoantibodies against IL-10 Linked to Severe Pediatric Inflammatory Bowel Disease and HLA-DRB1*01:03 Allele

By MedXY 08/12/2026

A multicategory study reveals 2.5% of pediatric IBD patients harbor IL-10-neutralising autoantibodies associated with severe disease and HLA-DRB1*01:03 allele, underscoring a distinct pathogenic subgroup.

Allergy & Immunology Critical Care news

Functional Impairment of Natural Killer Cells After Severe Trauma: Phenotypic Shifts and Loss of Activating Receptors

By MedXY 08/11/2026

Severe trauma induces maturation and cytotoxic phenotypes in NK cells but paradoxically decreases expression of activating receptors critical for immune defense, revealing a mechanism underlying posttrauma immune dysregulation and vulnerability to infection.

Allergy & Immunology Critical Care news

Dynamic Alterations in Natural Killer Cell Phenotype and Activating Receptor Expression Following Trauma: Insights into Immune Dysregulation

By MedXY 08/11/2026

Severe trauma induces phenotypic maturation of natural killer cells but leads to a loss of key activating receptors, potentially driving posttraumatic immune dysfunction and increased infection risk.

Allergy & Immunology news Respiratory

Decoding the Immune Landscape of COPD: Single-Cell RNA Sequencing Reveals Profibrotic Macrophage and Monocyte Niches Driving Disease Progression

By MedXY 08/04/2026

This study uses single-cell RNA sequencing of bronchoalveolar lavage cells to reveal immune dysregulation in COPD, highlighting profibrotic macrophages and monocytes as key players in airway remodeling and gas exchange impairment.

Critical Care Infectious Diseases news Pediatrics

Epstein-Barr Virus and Pediatric Sepsis: Unraveling Links to Immune Dysregulation and Mortality

By MedXY 10/27/2025

This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.

Clinical Updates Infectious Diseases news Specialties

Decoding Immune Dynamics in HBV-Related Acute-on-Chronic Liver Failure: Insights from Single-Cell Multimodal Analysis

By MedXY 09/04/2025

This longitudinal single-cell multiomics study delineates the evolving immune landscape in HBV-ACLF, identifying key immune cell subsets and signaling pathways that drive disease progression and highlight potential therapeutic targets for precision medicine.