Posted inGastroenterology news Oncology
Targeting IMPDH2-Induced Guanine Nucleotide Depletion to Enhance KRAS Inhibition in Pancreatic Cancer
An integrated genomic and pharmacologic analysis identifies IMPDH2 as a key vulnerability in KRAS-mutant pancreatic cancer, showing that irreversible guanine nucleotide depletion potentiates KRAS-targeted therapies and offers a novel combinational treatment avenue.