female infertility

Biallelic ANAPC13 Mutations Identify a New Genetic Cause of Oocyte Maturation Arrest

By MedXY 04/20/2026

Biallelic ANAPC13 variants caused metaphase I oocyte maturation arrest in three women and in a knock-in mouse model, implicating APC/C dysfunction as a new monogenic cause of female infertility.

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Genetic Discovery: ANAPC13 Mutations Cause Female Infertility Through Oocyte Maturation Arrest

By MedXY 04/20/2026

Researchers identified biallelic ANAPC13 mutations as a genetic cause of female infertility characterized by oocyte maturation arrest. The study demonstrated how these mutations disrupt cell division in both humans and mice, and explored a potential mRNA-based treatment approach.

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ANAPC13 Mutations Emerge as a New Genetic Cause of Oocyte Maturation Arrest

By MedXY 04/20/2026

Biallelic ANAPC13 mutations were linked to metaphase I oocyte maturation arrest in humans and mice, implicating APC/C dysfunction as a new genetic cause of female infertility and a potential future target for rescue strategies.