Exploring Over-the-Counter Herbal and Nutritional Products for Adult Depression: A Comprehensive Evidence Landscape

Exploring Over-the-Counter Herbal and Nutritional Products for Adult Depression: A Comprehensive Evidence Landscape

A scoping review of 209 trials reveals a concentrated evidence base for omega-3s, St John’s Wort, saffron, probiotics, and vitamin D in treating adult depression, highlights promising but under-researched herbal and supplement candidates, and underscores the need for improved safety reporting and integrative therapy evaluations.
Dissecting Depression in Diabetes: Distinct Links of Somatic and Cognitive Symptoms with Inflammation and Insulin Resistance

Dissecting Depression in Diabetes: Distinct Links of Somatic and Cognitive Symptoms with Inflammation and Insulin Resistance

New GRADE sub-study reveals that somatic symptoms of depression, not cognitive-affective symptoms, are chiefly associated with inflammation and insulin resistance in type 2 diabetes, highlighting a pathophysiological bridge for targeted interventions.