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Clinical Trial Design

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Challenging the Assumption: Fellow-Eye Correlations in Geographic Atrophy Progression Prove Modest at Best
Posted innews Ophthalmology

Challenging the Assumption: Fellow-Eye Correlations in Geographic Atrophy Progression Prove Modest at Best

Posted by MedXY By MedXY 04/11/2026
A post hoc analysis of AREDS2 reveals that geographic atrophy enlargement rates between fellow eyes show only modest correlations, challenging the common assumption that bilateral GA progresses similarly. The findings have important implications for clinical trial design and the use of fellow eyes as internal controls.
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