ANAPC13

Biallelic ANAPC13 variants caused metaphase I oocyte maturation arrest in three women and in a knock-in mouse model, implicating APC/C dysfunction as a new monogenic cause of female infertility.

Biallelic ANAPC13 mutations were linked to metaphase I oocyte maturation arrest in humans and mice, implicating APC/C dysfunction as a new genetic cause of female infertility and a potential future target for rescue strategies.