High-Dose Influenza Vaccine Fails to Significantly Reduce Combined Influenza and Pneumonia Hospitalizations: Insights from the DANFLU-2 Trial
Posted inInfectious Diseases news Public Health Respiratory

High-Dose Influenza Vaccine Fails to Significantly Reduce Combined Influenza and Pneumonia Hospitalizations: Insights from the DANFLU-2 Trial

The DANFLU-2 trial found that while high-dose influenza vaccines significantly reduced influenza-specific hospitalizations in older adults, they did not reach statistical significance for the combined primary endpoint of influenza or pneumonia hospitalizations compared to standard-dose vaccines.
Early-Life Famine Exposure in Chinese Immigrants Strongly Linked to Later Diabetes and Hypertension — But Not Cardiovascular Hospitalization
Posted inDiabetes & Endocrinology news Public Health

Early-Life Famine Exposure in Chinese Immigrants Strongly Linked to Later Diabetes and Hypertension — But Not Cardiovascular Hospitalization

A large Ontario cohort study links early-life exposure to the Great Chinese Famine with higher adult risks of type 2 diabetes and hypertension among Chinese immigrants, while cardiovascular hospitalization was not increased; methodological caveats underline need for age-balanced research.
School Feeding Programs: Comprehensive Evidence on Benefits for Socioeconomically Disadvantaged School Children’s Physical and Psychological Health
Posted inClinical Updates news Pediatrics Psychiatry Public Health

School Feeding Programs: Comprehensive Evidence on Benefits for Socioeconomically Disadvantaged School Children’s Physical and Psychological Health

This review synthesizes global evidence, including meta-analyses, showing that school feeding programs modestly improve math achievement, enrollment, and growth metrics in socioeconomically disadvantaged children, with limited effects on reading or attendance, and uncertain impact on overweight/obesity.
Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention
Posted inCardiology news Pediatrics Public Health

Elevated Blood Pressure in Adolescence Predicts Dose‑Dependent Coronary Atherosclerosis in Middle Age: Implications for Early Detection and Prevention

A Swedish cohort study of 10,222 men linked adolescent blood pressure to coronary atherosclerosis by CCTA ~40 years later; higher systolic BP in adolescence, even in the ‘elevated’ range, was associated with greater odds of severe (>50%) coronary stenosis in middle age.
Novel Type 1 and Type 3 Live Attenuated Oral Poliovirus Vaccines Show Comparable Safety, Immunogenicity, and Shedding to Sabin mOPV in First‑in‑Human Phase 1 Trial
Posted inInfectious Diseases news Public Health

Novel Type 1 and Type 3 Live Attenuated Oral Poliovirus Vaccines Show Comparable Safety, Immunogenicity, and Shedding to Sabin mOPV in First‑in‑Human Phase 1 Trial

A multicentre phase 1 trial in healthy US adults found nOPV1 and nOPV3 were well tolerated and induced robust homotypic neutralising antibody responses with shedding profiles similar to Sabin monovalent OPV, supporting progression to phase 2 studies.
Surgical aortic valve replacement produces about twice the carbon footprint of transcatheter approaches: clinical and stewardship implications
Posted inCardiology news Public Health

Surgical aortic valve replacement produces about twice the carbon footprint of transcatheter approaches: clinical and stewardship implications

A life cycle assessment found SAVR emits ~620–750 kg CO2e per case—roughly double OR- or cath-lab TAVR (~280–360 kg CO2e). ICU length of stay and postoperative care were the dominant contributors, highlighting targets for low-carbon perioperative pathways and policy-level decision-making.
Daily High‑Dose Mosnodenvir Significantly Lowers DENV‑3 Viremia in a Human Challenge — Proof‑of‑Concept with Early Resistance Signals
Posted inInfectious Diseases news Public Health

Daily High‑Dose Mosnodenvir Significantly Lowers DENV‑3 Viremia in a Human Challenge — Proof‑of‑Concept with Early Resistance Signals

In a phase 2a human challenge, high‑dose daily mosnodenvir substantially reduced DENV‑3 RNA burden versus placebo without serious adverse events, but treatment‑associated NS4B viral mutations emerged, highlighting efficacy and resistance concerns that require larger field studies.
Combining Food Biodiversity, Less Processing, and the EAT‑Lancet Diet Improves Nutrient Adequacy and Lowers Environmental Impact: Insights from 368,733 EPIC Participants
Posted inFamily Medicine & Nutrition news Public Health

Combining Food Biodiversity, Less Processing, and the EAT‑Lancet Diet Improves Nutrient Adequacy and Lowers Environmental Impact: Insights from 368,733 EPIC Participants

Multi-objective optimization in the EPIC cohort shows that modest gains in adherence to the EAT‑Lancet diet, increased plant species richness, and substitution of ultra‑processed foods with minimally processed foods can raise nutrient adequacy and reduce greenhouse gas emissions and land use.