The Long Shadow of the ICU: Identifying High-Risk Functional Trajectories in Older Survivors
Posted inCritical Care news Public Health

The Long Shadow of the ICU: Identifying High-Risk Functional Trajectories in Older Survivors

A large-scale longitudinal study reveals that ICU survivors aged 60–79 face significantly higher 5-year excess mortality and functional decline compared to the general population, whereas outcomes for nonagenarians converge with their peers, highlighting a critical window for geriatric intervention and advance care planning.
High-Dose Influenza Vaccination Reduces Hospitalizations and Cardiovascular Events in Older Adults: Insights from the FLUNITY-HD Pooled Analysis
Posted inCardiology Infectious Diseases news Public Health

High-Dose Influenza Vaccination Reduces Hospitalizations and Cardiovascular Events in Older Adults: Insights from the FLUNITY-HD Pooled Analysis

The FLUNITY-HD pooled analysis of over 466,000 older adults demonstrates that high-dose inactivated influenza vaccine (HD-IIV) significantly reduces hospitalizations for influenza, pneumonia, and cardiovascular causes, including a 21.3% reduction in heart failure admissions, compared to standard-dose vaccines.
Individualized Feedback Letters Fail to Reduce Long-Term Alcohol Consumption: Insights from a 4-Year RCT
Posted innews Psychiatry Public Health

Individualized Feedback Letters Fail to Reduce Long-Term Alcohol Consumption: Insights from a 4-Year RCT

A 4-year randomized controlled trial found that computer-generated feedback letters failed to reduce alcohol consumption in the general population. Unexpectedly, the control group showed greater reduction at 48 months, suggesting that current digital intervention strategies may require significant adaptation for low-risk drinkers.
Optimizing Opioid Use Disorder Treatment: When Does 300 mg Outperform 100 mg of Extended-Release Buprenorphine?
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Optimizing Opioid Use Disorder Treatment: When Does 300 mg Outperform 100 mg of Extended-Release Buprenorphine?

This randomized clinical trial compares 100-mg and 300-mg maintenance doses of extended-release buprenorphine. While overall efficacy was similar, the 300-mg dose significantly improved abstinence among patients with high-frequency fentanyl use, suggesting a need for dose-intensification in the era of potent synthetic opioids.
High-Dose Influenza Vaccine Fails to Significantly Reduce Combined Influenza and Pneumonia Hospitalizations: Insights from the DANFLU-2 Trial
Posted inInfectious Diseases news Public Health Respiratory

High-Dose Influenza Vaccine Fails to Significantly Reduce Combined Influenza and Pneumonia Hospitalizations: Insights from the DANFLU-2 Trial

The DANFLU-2 trial found that while high-dose influenza vaccines significantly reduced influenza-specific hospitalizations in older adults, they did not reach statistical significance for the combined primary endpoint of influenza or pneumonia hospitalizations compared to standard-dose vaccines.