Public Health – Medxy AI

Tomatine: A Novel Natural Adjuvant Enhancing mRNA Vaccine Efficacy in Cancer and Infectious Diseases

By MedXY 10/22/2025

Tomatine, a natural compound incorporated into mRNA vaccine nanocarriers, significantly enhances antigen expression and innate immune activation, boosting adaptive immunity against tumors and SARS-CoV-2, underscoring its potential as a versatile vaccine adjuvant.

Infectious Diseases news Public Health

Decoding Multidrug-Resistant Tuberculosis in Hainan Island: Linking Genotypes to Resistance Levels for Optimized Treatment

By MedXY 10/22/2025

This study elucidates drug resistance patterns and genotype-phenotype correlations in multidrug-resistant Mycobacterium tuberculosis strains from Hainan Island, China, revealing implications for tailored MIC-based therapies.

Infectious Diseases Public Health Specialties

Unmasking the Silent Spread: Screening Asymptomatic Tuberculosis in Household Contacts in South Africa

By MedXY 10/22/2025

This study reveals that over 80% of tuberculosis cases among South African household contacts are asymptomatic and often missed by symptom and chest X-ray screening, highlighting the need for improved diagnostic strategies to detect subclinical TB.

Psychiatry Public Health Specialties

Decoding Conspiratorial Thinking Across America: Insights from a Nationwide Survey

By MedXY 10/22/2025

A comprehensive 50-state survey reveals widespread conspiratorial thinking among American adults linked to demographic factors and COVID-19 vaccine hesitancy, with implications for public health strategies.

Cardiology news Public Health

Active Monitoring for Atrial Fibrillation (AMALFI): Advancing Long-Term Remote Screening to Reduce Stroke Risk

By MedXY 10/21/2025

The AMALFI trial evaluates remote screening for asymptomatic atrial fibrillation in older adults to improve detection, anticoagulation use, and reduce stroke risk, with findings pending follow-up at 2.5 and 5 years.

Cardiology news Public Health

Remote ECG Patch Screening for Asymptomatic Atrial Fibrillation: Insights from the AMALFI Trial

By MedXY 10/21/2025

The AMALFI trial demonstrates that remote, mail-based 14-day ECG patch screening modestly increases long-term atrial fibrillation detection and anticoagulation use in older adults at stroke risk, with no observed reduction in stroke at 2.5 years.

Neurology Public Health Specialties

Comparative Performance of Dementia Risk Indices in the HUNT Study: Insights into CogDrisk, LIBRA, CAIDE, and More

By MedXY 10/21/2025

This study compares five dementia risk indices using data from the HUNT study, revealing CogDrisk as the most accurate predictor, though none outperformed a demographics-only model including age and education.

Neurology news Pathology & Lab Medicine Public Health

Moderate-to-Vigorous Physical Activity, p-tau181, and Cognition in Older Adults with Memory Complaints: Insights from the MAPT Study

By MedXY 10/20/2025

Higher moderate-to-vigorous physical activity slows p-tau181 increase, a marker of Alzheimer’s pathology, but elevated p-tau181 diminishes exercise-related cognitive benefits in older adults.

Critical Care Emergency Medicine news Public Health Specialties

Empowering Older Adults in Acute Care: Insights on Shared Decision Making for Treatment Escalation Planning

By MedXY 10/20/2025

This qualitative UK study explores older patients' perspectives on shared decision making for treatment escalation during acute hospital deterioration, highlighting the need for patient autonomy, education, and adaptable clinical approaches.

HIV/AIDS Infectious Diseases Public Health Specialties

HIV Among Older Adults in Sub-Saharan Africa: Epidemiology, Risks, and Treatment Insights from the AWI-Gen Longitudinal Study

By MedXY 10/20/2025

This multicentre longitudinal cohort study reveals significant HIV prevalence and incidence among adults aged 40 and older in sub-Saharan Africa, highlighting age, gender, education, and rural residency as critical factors influencing HIV risk and treatment outcomes.

Internal Medicine news Public Health

Optimizing Healthy Ageing: The Impact of Physical Activity and Sedentary Behavior on Intrinsic Capacity in Older Adults

By MedXY 10/20/2025

This prospective Spanish cohort study reveals that moderate-to-vigorous physical activity enhances intrinsic capacity in older adults, while sedentary behavior impairs it, underscoring the role of active lifestyles in promoting healthy ageing.

Internal Medicine Public Health Specialties

Unraveling the Hidden and Measured Drivers of Chronic Disease Accumulation Across Organ Systems

By MedXY 10/20/2025

A 30-year birth cohort study reveals that life-course factors, especially modifiable markers like BMI, blood glucose, and blood pressure, significantly influence the buildup of chronic diseases across eight organ systems, yet much remains unexplained, prompting further research.

Neurology news Public Health

Evolving Landscape of Modifiable Dementia Risk Factors in Australia: Socioeconomic and Sex Disparities Over 15 Years

By MedXY 10/20/2025

This analysis reveals stable dementia risk fractions despite changing risk profiles over 15 years in Australia, highlighting greater modifiable risk among low-income groups and males, with depression emerging as a leading factor in mid-life, especially in women and disadvantaged populations.

Internal Medicine news Public Health

Global Mortality Trends 1990-2023: Insights from the GBD 2023 Study on Causes of Death

By MedXY 10/20/2025

The GBD 2023 Study integrates data from 204 countries to reveal shifting global mortality patterns, emphasizing the impact of COVID-19, declining vaccine-preventable deaths, and rising non-communicable diseases, highlighting critical areas for targeted public health action.

Diabetes & Endocrinology news Public Health

Leveraging the Planetary Health Diet to Reduce Type 2 Diabetes Risk and Environmental Impact: Insights from the EPIC-Norfolk Study

By MedXY 10/20/2025

Higher adherence to the planetary health diet is linked with a 32% reduced risk of type 2 diabetes and significantly lower greenhouse gas emissions, supporting its role in preventing diabetes and promoting sustainability.

Diabetes & Endocrinology Family Medicine & Nutrition Public Health Specialties

Planetary Health and Plant-Based Diets: Reducing Type 2 Diabetes Risk in UK Adults

By MedXY 10/20/2025

Higher adherence to the Planetary Health Diet Index, reflecting environmentally sustainable plant-based eating patterns, is strongly associated with reduced type 2 diabetes risk in UK Biobank participants, comparable or superior to other established plant-based diet scores.

Internal Medicine news Public Health

Extending the Hospital Frailty Risk Score to All Adults: Implications for Hospital Stay, Mortality, and Costs in England

By MedXY 10/20/2025

The Hospital Frailty Risk Score (HFRS) predicts length of stay, mortality, and costs across all adult age groups in England, with stronger effects in older adults, supporting broader clinical use beyond the elderly.

Neurology news Public Health

Age-Dependent Impact of Vascular Risk Factors on Acute Stroke: Insights from the INTERSTROKE Study

By MedXY 10/20/2025

The INTERSTROKE study reveals how age modifies the relationship between vascular risk factors and acute stroke, highlighting age-specific prevention priorities to reduce stroke burden globally.

news Psychiatry Public Health

Global Trends and Method-Specific Suicide Mortality Among Older Adults: Insights and Projections to 2050

By MedXY 10/20/2025

A comprehensive study spanning 47 countries reveals changing suicide mortality rates among adults aged 65+, highlighting method-specific risks and projecting future trends amid global population ageing.

Neurology Public Health Specialties

Life Course Air Pollution Exposure Linked to Cognitive Decline and Brain Structural Changes in Older Adults

By MedXY 10/20/2025

A population-based study reveals that midlife exposure to air pollutants such as nitrogen dioxide and particulate matter is associated with cognitive decline and brain structural alterations by age 69-71, highlighting long-term neurological risks of ambient air pollution.