Psychiatry – Page 6

Neurobiological Impact of Emotion-Focused Parenting Intervention in Adolescent Girls With Internalizing Symptoms: Insights From a Randomized Clinical Trial

By MedXY 10/29/2025

An emotion-focused parenting intervention improves prefrontal cortex activation during emotion regulation in adolescent girls with internalizing symptoms, correlating with reductions in maternal unsupportive socialization and adolescent anxiety.

news Psychiatry

Evaluating Antidepressant Impact on Bipolar Depression: Insights from a Propensity Score Analysis in the STEP-BD Cohort

By MedXY 10/27/2025

A propensity score analysis of STEP-BD data reveals no significant association between antidepressant use and either manic switch risk or symptomatic remission in bipolar depression, highlighting the need for alternative treatment strategies.

Neurology news Psychiatry

Unlocking the Predictive Power of Plasma Biomarkers for Early Alzheimer’s Disease Detection

By MedXY 10/27/2025

This review evaluates recent evidence on plasma AD biomarkers, especially phosphorylated tau217 and amyloid PET, for predicting cognitive decline in unimpaired individuals, highlighting their potential and limitations.

Clinical Updates news Psychiatry

Functional Connectivity as a Predictor of Transdiagnostic Treatment Outcomes in Internalizing Psychopathologies: Advances and Clinical Implications

By MedXY 10/27/2025

Whole-brain functional connectivity patterns predict multidimensional treatment outcomes across internalizing psychopathologies and various therapies, highlighting neural network biomarkers for personalized psychiatric care.

news Pediatrics Psychiatry

Early Diagnosis and Treatment Patterns of ADHD in Preschool Children: Insights from a National Electronic Health Record Study

By MedXY 10/27/2025

This study analyzes the diagnosis and medication initiation of ADHD among children aged 3-5 across multiple US health systems, highlighting sociodemographic disparities and clinical practices.

news OB/GYN & Women's Health Psychiatry

Behavioral Activation Reduces Perinatal Suicide Ideation: Insights from the SUMMIT Trial

By MedXY 10/27/2025

A secondary analysis of the SUMMIT trial shows that brief behavioral activation therapy significantly reduces suicide ideation in perinatal women, regardless of clinician type or treatment modality, highlighting a scalable approach for suicide prevention in this vulnerable population.

Neurology news Psychiatry

Regional Specificity of Layer 3 Dendritic Spine Deficits in Schizophrenia: Implications for Cortical Circuit Dysfunction

By MedXY 10/27/2025

This study reveals region- and size-specific dendritic spine deficits in cortical layer 3 neurons of schizophrenia patients, highlighting differential synaptic disruptions across visual and prefrontal cortical areas underpinning cognitive deficits.

news Psychiatry Public Health

Gamified mHealth Strategies Boost Treatment Adherence and Outcomes in Late-Life Depression

By MedXY 10/27/2025

Implementing gamification in mobile health psychotherapy markedly improves adherence and reduces depressive symptoms among older adults, offering a promising avenue to address mental health care needs in aging populations.

news Psychiatry

Evaluating Pramipexole as Adjunct Therapy in Treatment-Resistant Bipolar Depression: Insights from the PAX-BD Trial

By MedXY 10/24/2025

The PAX-BD trial assessed pramipexole addition to mood stabilisers in treatment-resistant bipolar depression, revealing some mood and psychosocial benefits but no significant primary outcome improvement, highlighting the need for further research.

news Psychiatry

Evaluating Serial Ketamine Infusions as Adjuncts in Inpatient Depression Care: Insights from the KARMA-Dep 2 Trial

By MedXY 10/24/2025

The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term antidepressant benefits in this setting.

Pediatrics Psychiatry Public Health

Silent Long-Term Harm: How Prenatal Lead Exposure Shapes Adult Mental Health

By MedXY 10/24/2025

This article explores the link between prenatal and early postnatal lead exposure and adult anxiety and depression, emphasizing critical exposure windows and long-term mental health implications.

news Psychiatry Public Health

Unlocking the Complexity of Co-Occurring Chronic Pain and Psychological Distress in Young Adults: Insights from Machine Learning and Explainable AI

By MedXY 10/24/2025

This study applies machine learning and explainable AI to identify factors associated with chronic pain, psychological distress, and their co-occurrence in Norwegian young adults, highlighting the importance of integrated approaches for early intervention.

Clinical Updates Psychiatry Public Health

Long-Term Exposure to Air Pollution and Road Traffic Noise: Associations with Antidepressant Medication Dispensing in Swedish Adults

By MedXY 10/23/2025

This review synthesizes evidence linking long-term air pollution and road traffic noise exposure with antidepressant medication dispensing, highlighting sex-specific associations and implications for mental health prevention strategies.

Psychiatry Public Health Specialties

Long-Term PM2.5 Exposure and Mental Health Disparities: Insights from the All of Us Research Program

By MedXY 10/22/2025

This prospective study reveals that prolonged exposure to fine particulate matter (PM2.5) significantly elevates risks of depression and anxiety, disproportionately affecting Black populations due to systemic inequities. Findings call for targeted environmental and public health interventions.

Psychiatry Specialties

Reducing Suicide Risk in Bipolar Disorder: The Impact of Lithium, Valproate, and Atypical Antipsychotics in Long-Term Treatment

By MedXY 10/22/2025

This study reveals that long-term treatment with lithium or valproate significantly lowers suicide risks in bipolar disorder patients. Combining atypical antipsychotics with these mood stabilizers further reduces suicide incidence, offering critical insights for managing high-risk individuals.

Psychiatry Public Health Specialties

Decoding Conspiratorial Thinking Across America: Insights from a Nationwide Survey

By MedXY 10/22/2025

A comprehensive 50-state survey reveals widespread conspiratorial thinking among American adults linked to demographic factors and COVID-19 vaccine hesitancy, with implications for public health strategies.

Diabetes & Endocrinology Psychiatry Specialties

Semaglutide for Metabolic Health in Schizophrenia: Insights from the HISTORI RCT

By MedXY 10/22/2025

The HISTORI trial demonstrates that semaglutide significantly improves glycemic control, reduces weight, and enhances physical quality of life in schizophrenia patients treated with second-generation antipsychotics, without worsening psychiatric symptoms.

news Psychiatry

Azetukalner: A Novel KV7 Potassium Channel Opener Shows Promise in Treating Major Depressive Disorder

By MedXY 10/21/2025

Azetukalner, a KV7 potassium channel opener, demonstrated clinically meaningful antidepressant effects and significant improvement in anhedonia in adults with major depressive disorder in a 6-week randomized trial, supporting further development.

Internal Medicine Psychiatry Specialties

Single-Dose MM120 (Lysergide) Shows Promise in Treating Generalized Anxiety Disorder: Phase 2b RCT Results

By MedXY 10/21/2025

A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.

Neurology news Pathology & Lab Medicine Psychiatry Specialties

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies

By MedXY 10/21/2025

Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.