Specialties – Page 20

Persistent Healthcare Burden in Women with Chest Pain Despite No Obstructive Coronary Artery Disease: Insights from the WOMANOCA Study

By MedXY 01/04/2026

A nationwide Danish cohort study reveals that women with angina or non-specific chest pain and no obstructive coronary artery disease face significantly higher rates of cardiac readmissions and primary care consultations compared to asymptomatic peers, highlighting a substantial healthcare burden.

Cardiology Diabetes & Endocrinology news

Semaglutide Extends Survival in Non-Overweight Type 2 Diabetes Patients: New Evidence Challenges BMI-Centric Treatment Models

By MedXY 01/04/2026

A large-scale retrospective study demonstrates that semaglutide reduces all-cause mortality by 46% in non-overweight patients with Type 2 diabetes compared to DPP-4 inhibitors, highlighting cardioprotective benefits independent of weight reduction.

Cardiology news

Is Female Sex a Truly Independent Risk Factor for Stroke in Atrial Fibrillation? Insights from a Large European Cohort

By MedXY 01/04/2026

A large European cohort study reveals that while women with atrial fibrillation are less likely to receive anticoagulants and show higher crude thromboembolism rates, female sex is not an independent risk factor after adjusting for comorbidities. The CHA2DS2-VASc score remains superior for clinical reclassification.

Cardiology Internal Medicine news

NSAID Co-prescription in Atrial Fibrillation: Doubling the Bleeding Burden Across All Oral Anticoagulants

By MedXY 01/04/2026

A nationwide cohort study demonstrates that NSAID use in patients with atrial fibrillation on oral anticoagulants nearly doubles the risk of hospital-diagnosed bleeding, with significant risks observed across all anticoagulant types and multiple anatomical sites.

AI Cardiology news

AI-Based OCT Analysis Outperforms Human Experts in Predicting Outcomes from Non-Culprit Lesions: Insights from the PECTUS-AI Study

By MedXY 01/03/2026

The PECTUS-AI study demonstrates that AI-based identification of thin-cap fibroatheromas using OCT provides superior prognostic value for cardiovascular events compared to manual analysis, particularly when assessing the entire imaged coronary segment, offering a standardized approach to identifying high-risk patients.

Cardiology news Radiology

Beyond Body Mass Index: How Sex-Specific Fat Distribution Drives Cardiovascular Ageing

By MedXY 01/03/2026

A large-scale UK Biobank study reveals that while visceral and liver fat accelerate cardiovascular ageing in both sexes, subcutaneous and android fat specifically impact males, whereas gynoid fat may offer protective benefits.

Cardiology news Radiology

Elevated LDL-C Increases Cardiovascular Risk in Symptomatic Patients Despite a Coronary Calcium Score of Zero

By MedXY 01/03/2026

A large-scale cohort study from the Western Denmark Heart Registry demonstrates that high LDL-C remains a significant predictor of non-calcified plaque and coronary heart disease events in patients with a CAC score of zero, particularly among those aged 45 and younger.

Cardiology news Radiology

Tracking the Invisible: CMR-ECV Mapping Reveals Amyloid Stabilization with Patisiran and Predicts Mortality in ATTR-CM

By MedXY 01/03/2026

A landmark study demonstrates that CMR-derived extracellular volume (ECV) mapping effectively monitors amyloid burden in ATTR-CM. While untreated patients show significant progression, patisiran stabilizes amyloid load, with ECV progression serving as a potent independent predictor of mortality.

Cardiology news Psychiatry

Mental Health Labels Linked to Critical Delays and Doubled Five-Year Mortality in STEMI Care

By MedXY 01/03/2026

A prospective study reveals that patients with mental health conditions face significant delays in STEMI diagnosis, resulting in larger infarct sizes and a twofold increase in five-year cardiovascular mortality compared to those without such conditions.

Cardiology news

Win Ratio Analysis Confirms No Net Benefit for Anticoagulation in Device-Detected Atrial Fibrillation

By MedXY 01/03/2026

A hierarchical win ratio analysis of the NOAH-AFNET 6 trial confirms that edoxaban does not provide a net clinical benefit over no anticoagulation in patients with device-detected atrial fibrillation, primarily due to the balance between low stroke rates and significant bleeding risks.

Cardiology news Public Health

Timing Matters: Delayed Statin Initiation After Incidental High LDL-C Detection Significantly Increases Myocardial Infarction Risk

By MedXY 01/03/2026

A large-scale cohort study demonstrates that delaying statin therapy following the incidental discovery of high LDL-C during routine health screenings leads to a progressively higher risk of myocardial infarction, emphasizing the critical importance of early pharmacological intervention.

Cardiology news

Baseline Risk Does Not Resuscitate PCI Benefit in Ischemic Cardiomyopathy: Lessons from the REVIVED-BCIS2 Sub-analysis

By MedXY 01/03/2026

A prespecified analysis of the REVIVED-BCIS2 trial reveals that baseline risk of death or hospitalization does not modify the effectiveness of PCI in patients with ischemic left ventricular dysfunction, reinforcing the primacy of optimal medical therapy.

Cardiology news

The 30-Day Ischemic Penalty: Why Early Aspirin Withdrawal in ACS Requires Caution

By MedXY 01/03/2026

A landmark analysis from the NEOMINDSET trial demonstrates that while potent P2Y12 inhibitor monotherapy reduces bleeding, it significantly increases ischemic risk in the first 30 days after PCI for acute coronary syndrome, suggesting that the timing of aspirin withdrawal is critical for patient safety.

Cardiology Critical Care news

High-Acuity Presentations with Favorable Outcomes: The Paradox of Young Adults in the Cardiac ICU

By MedXY 01/03/2026

A large-scale registry study reveals that young adults (18-39) in the Cardiac Intensive Care Unit present with higher rates of cardiogenic shock and cardiac arrest compared to older adults, yet demonstrate significantly higher survival rates despite more intensive resource utilization.

Cardiology news

Subcutaneous ICDs in the Real World: Lessons from the French Nationwide HONEST Study

By MedXY 01/03/2026

The nationwide HONEST study provides critical five-year data on S-ICD performance, highlighting a 13.8% inappropriate shock rate, the protective effect of SMART Pass filtering, and unexpected challenges with battery longevity in a large, unselected patient population.

Cardiology news

M-TEER Benefits in Secondary Mitral Regurgitation: Consistent Clinical and Quality-of-Life Improvements Regardless of Baseline Health Status

By MedXY 01/03/2026

The RESHAPE-HF2 trial reveals that mitral transcatheter edge-to-edge repair (M-TEER) significantly reduces cardiovascular risks and enhances health status across all baseline patient conditions, reinforcing its role as a key intervention for symptomatic heart failure and secondary mitral regurgitation.

Cardiology news

Precision Risk Assessment in CPVT: New Validated Models Predict Arrhythmic Events on Beta-Blocker Therapy

By MedXY 01/03/2026

A landmark study has developed and validated the first clinical risk prediction models for RYR2-mediated CPVT, identifying key factors like age at treatment and prior symptoms that determine life-threatening outcomes despite beta-blocker therapy.

Cardiology news

FFR-Guided Revascularization Significantly Reduces 12-Month MACCE in TAVI Patients: The FAITAVI Trial

By MedXY 01/03/2026

The FAITAVI trial demonstrates that physiology-guided PCI using FFR significantly reduces major adverse cardiac events, particularly mortality, compared to angiography-guided PCI in elderly patients undergoing TAVI with intermediate coronary lesions.

Cardiology Emergency Medicine news

Hypertensive Response in Advanced Conduction Disorders: A Paradoxical Marker of Haemodynamic Resilience?

By MedXY 01/03/2026

Recent research reveals that nearly half of patients with high-degree AV block present with hypertension, a phenotype characterized by preserved cardiac function and higher peripheral vascular resistance, leading to better short-term clinical outcomes compared to normotensive or unstable patients.

Cardiology news

Beyond the Mutation: Uncovering the Triggers of Disease Onset in Titin-Related Dilated Cardiomyopathy

By MedXY 01/03/2026

An international multicenter study reveals that while Titin-truncating variants significantly increase cardiomyopathy risk, disease onset is heavily influenced by male sex, co-morbidities, and atrial fibrillation, while early prophylactic therapy may offer substantial protection.