Ophthalmology – Medxy AI

Clinical Findings and Molecular Genetics of USH1C-Associated Usher Syndrome: A Retrospective Case Series

By MedXY 11/27/2025

This case series reviews clinical features, genetic variants, visual outcomes, and psychosocial impact in 28 patients with USH1C-associated Usher syndrome, highlighting slow retinal degeneration and significant social burden.

news Ophthalmology Pediatrics

Rigid Gas-Permeable Contact Lenses Improve Visual Rehabilitation After Primary Congenital Glaucoma Surgery: Results of the CLEVR‑PCG Randomized Trial

By MedXY 11/25/2025

In children after primary congenital glaucoma surgery with poor spectacle response, rigid gas‑permeable contact lenses produced greater improvements in worse‑eye visual acuity, contrast sensitivity, and near stereoacuity over 12 months compared with continued spectacle wear.

news Ophthalmology Pediatrics

Five-Year Visual Outcomes After Lensectomy for Childhood Traumatic Cataract: Modest Vision Gains but High Rates of Visual Axis Opacification in Pseudophakia

By MedXY 11/25/2025

A prospective PEDIG cohort found modest long-term vision after lensectomy for pediatric traumatic cataract, low 5-year glaucoma prevalence, and high 5-year surgery rates for visual axis opacification in pseudophakic eyes, especially without anterior vitrectomy.

news Ophthalmology

Manual Marking Without Special Equipment Is Noninferior to Digital Guidance for Capsulorhexis Accuracy in Phacoemulsification

By MedXY 11/25/2025

A randomized noninferiority trial found that a device-free manual marking-assisted capsulorhexis (MMAC) produced capsulorhexis diameters and centration comparable to digital guidance (DGAC), supporting a low-cost, widely applicable technique for routine cataract surgery.

AI news Ophthalmology

Foundation Models Narrow the Knowledge Gap in Ophthalmology but Struggle with Images

By MedXY 11/25/2025

Contemporary foundation models match experts on text-only ophthalmology exam questions but underperform on image-based items; targeted multimodal training and prospective validation are needed before clinical deployment.

Diabetes & Endocrinology news Ophthalmology Pathology & Lab Medicine

Indole-3-Propionic Acid Bridges Gut Dysfunction and Diabetic Retinopathy — A Biomarker and Therapeutic Avenue

By MedXY 11/09/2025

A Gut 2025 study identifies microbially produced indole-3-propionic acid (IPA) as a protective metabolite linking restored intestinal tryptophan handling to prevention of diabetic retinopathy in mice and associates low serum IPA with retinopathy in people with type 2 diabetes.

news Ophthalmology Pediatrics

Understanding the FDA’s Rejection of SYD-101: Navigating the Challenges in Pediatric Myopia Treatment

By MedXY 11/04/2025

The FDA has rejected Sydnexis's low-dose atropine eye drop SYD-101 for controlling childhood myopia progression despite promising trial results, highlighting challenges in demonstrating long-term efficacy and clinical significance in new pediatric myopia therapies.

news Ophthalmology

Biodegradable Aflibercept Microsphere‑Hydrogel Shows Long‑Term Ocular Biocompatibility in Rhesus Macaques

By MedXY 11/03/2025

A biodegradable PLGA microsphere–thermo‑responsive hydrogel delivering aflibercept was well tolerated after single intravitreal injection in 23 rhesus macaques with preserved retinal structure and function up to 24 months.

news Ophthalmology

Cenegermin Eye Drops Show High Healing Rates in Chinese Patients with Moderate–Severe Neurotrophic Keratopathy

By MedXY 11/02/2025

A prospective phase IV open‑label Chinese study found cenegermin achieved corneal healing in 84.6% of stage 2/3 neurotrophic keratopathy patients at 8 weeks, with durable effects through 56 weeks and an acceptable safety profile.

Diabetes & Endocrinology news Ophthalmology

Long-Term Progression and Risk Factors of Diabetic Retinopathy in Type 2 Diabetes: Insights from the Skaraborg Cohort in Sweden

By MedXY 10/31/2025

This cohort study tracks diabetic retinopathy incidence over 24 years in type 2 diabetes patients, highlighting the impact of glycemic control and hypertension on disease progression.

Diabetes & Endocrinology news Ophthalmology

Glucagon-Like Peptide-1 Receptor Agonists and Ocular Risks: A Comprehensive Review of Neovascular AMD, Diabetic Retinopathy, and Ischemic Optic Neuropathy in Diabetes

By MedXY 10/29/2025

GLP-1 receptor agonists used in diabetes show a twofold increased risk of neovascular AMD, a modest risk elevation for diabetic retinopathy, and a small but significant increased risk for nonarteritic anterior ischemic optic neuropathy, warranting careful ophthalmic monitoring.

Diabetes & Endocrinology news Ophthalmology

Glucagon-Like Peptide-1 Receptor Agonists May Lower the Risk of Nonexudative Age-Related Macular Degeneration in Obese Non-Diabetic Adults

By MedXY 10/26/2025

A large retrospective cohort study reveals that GLP-1 receptor agonists significantly reduce the risk of developing nonexudative age-related macular degeneration in obese individuals without diabetes, with no effect on progression to exudative AMD.

Hematology-Oncology news Ophthalmology

Advances in Targeted and Gene Therapies: Promising Data on KRAS G12D Inhibitors, DR5 Agonists, and Ocular Gene Therapy

By MedXY 10/24/2025

Recent clinical trials report encouraging tumor shrinkage with KRAS G12D inhibitor VS-7375, significant progression-free survival benefit in soft tissue sarcoma with ozekibart, and a novel gene therapy acquisition targeting wet AMD.

Diabetes & Endocrinology news Ophthalmology

Impact of Multifactorial Interventions on Retinopathy in Type 2 Diabetes: Insights from the J-DOIT3 Trial

By MedXY 10/24/2025

This analysis highlights how intensive multifactorial management and glycemic control influence diabetic retinopathy onset, emphasizing the risks associated with hypoglycemia despite good glycemic control.

Ophthalmology Specialties

Intravenous Alteplase Versus Oral Aspirin in Acute Central Retinal Artery Occlusion: Insights from the THEIA Phase 3 Trial and Contextual Evidence

By MedXY 10/22/2025

THEIA trial evaluated intravenous alteplase against oral aspirin in acute CRAO within 4.5 hours; no significant visual improvement difference was found, emphasizing the need for further research and meta-analyses to clarify thrombolysis benefits.

Diabetes & Endocrinology Ophthalmology Specialties

IBI311, an IGF-1R Inhibitor, Shows Promising Results for Active Thyroid Eye Disease in Chinese Patients: Insights from the RESTORE-1 Trial

By MedXY 10/15/2025

The RESTORE-1 phase 3 trial demonstrates that IBI311 significantly improves proptosis and inflammation in Chinese patients with active thyroid eye disease, with a favorable safety profile.

Neurology news Ophthalmology

Vogt-Koyanagi-Harada Syndrome Presenting with Ophthalmic and Neurological Symptoms: A Case Report

By MedXY 10/05/2025

A 38-year-old male with bilateral blurred vision and neurological symptoms was diagnosed with Vogt-Koyanagi-Harada syndrome and managed successfully with corticosteroids and immunosuppressants.

Clinical Updates news Ophthalmology Specialties

Nonmedical Factors Impacting Quality of Care in Newly Diagnosed Primary Open-Angle Glaucoma Patients

By MedXY 09/28/2025

This study reveals that socioeconomic status, residential location, and household composition significantly affect treatment outcomes and follow-up in newly diagnosed POAG patients, highlighting the need for targeted strategies to improve glaucoma care equity.