Beyond Total Area: The GAWAIN Index Bridges the Gap Between Retinal Structure and Functional Vision in Geographic Atrophy
Posted innews Ophthalmology

Beyond Total Area: The GAWAIN Index Bridges the Gap Between Retinal Structure and Functional Vision in Geographic Atrophy

Researchers have developed and validated GAWAIN, a novel structural measure for geographic atrophy that weights macular regions by their functional importance. This index correlates significantly better with visual acuity than traditional area-based measurements, potentially revolutionizing clinical trial endpoints.
Quantitative Retinal Leakage on Ultra-Widefield Imaging: A New Biomarker for Predicting Diabetic Retinopathy Progression
Posted inDiabetes & Endocrinology news Ophthalmology

Quantitative Retinal Leakage on Ultra-Widefield Imaging: A New Biomarker for Predicting Diabetic Retinopathy Progression

A post hoc analysis of the DRCR Retina Network Protocol AA reveals that automated quantitative leakage index on ultra-widefield fluorescein angiography independently predicts the 4-year risk of DRSS worsening and vision-threatening complications in patients with nonproliferative diabetic retinopathy.
NT-501 Encapsulated Cell Therapy Successfully Slows Photoreceptor Loss in Macular Telangiectasia Type 2: Results from Two Phase 3 Trials
Posted innews Ophthalmology

NT-501 Encapsulated Cell Therapy Successfully Slows Photoreceptor Loss in Macular Telangiectasia Type 2: Results from Two Phase 3 Trials

Two Phase 3 trials show that NT-501 encapsulated cell therapy significantly reduces ellipsoid zone area loss in Macular Telangiectasia Type 2. While functional outcomes were inconsistent, the treatment demonstrated a robust neuroprotective effect against photoreceptor degeneration over 24 months.
Medical and Surgical Treatments for Neurotrophic Keratopathy: What Randomized Trials Tell Us (and What They Don’t)
Posted innews Ophthalmology

Medical and Surgical Treatments for Neurotrophic Keratopathy: What Randomized Trials Tell Us (and What They Don’t)

A Cochrane review of seven RCTs (494 participants) finds low- to very low-certainty evidence that select medical therapies — notably recombinant human nerve growth factor — may improve corneal re-epithelialization in neurotrophic keratopathy; evidence on vision, sensitivity, and surgical options remains inconclusive.