Fertility-Preserving Hormonal Therapy vs Hysterectomy in Early-Stage Endometrial Cancer: Survival Outcomes and Clinical Implications

Fertility-Preserving Hormonal Therapy vs Hysterectomy in Early-Stage Endometrial Cancer: Survival Outcomes and Clinical Implications

This analysis compares survival in young women with early-stage endometrial cancer treated with fertility-preserving hormonal therapy versus hysterectomy, highlighting survival equivalence in women under 40 years and increased mortality risk in older patients undergoing hormonal therapy.
Impact of Maternal Trace Element Levels on Neonatal Growth Among Diabetic and Non-Diabetic Pregnancies

Impact of Maternal Trace Element Levels on Neonatal Growth Among Diabetic and Non-Diabetic Pregnancies

A case–control study reveals that elevated copper levels in diabetic pregnant women negatively affect newborn weight and head circumference, while chromium correlates positively with birth length. Smoking exposure adversely impacts infants’ weight, underscoring maternal trace element status and lifestyle as key determinants of neonatal outcomes.
Association of Hysterectomy With Hypertension Incidence in Korean Women: Insights from a Nationwide Cohort Study

Association of Hysterectomy With Hypertension Incidence in Korean Women: Insights from a Nationwide Cohort Study

This nationwide Korean cohort study found that hysterectomy is associated with a modestly increased risk of developing hypertension in women aged 40 to 59 years, particularly in those with elevated post-surgical hemoglobin levels and after adnexa-sparing procedures.
Revealing Metabolic Subtypes in Gestational Diabetes Using Dynamic OGTT-Derived C-Peptide Trajectories: Implications for Personalized Risk and Management

Revealing Metabolic Subtypes in Gestational Diabetes Using Dynamic OGTT-Derived C-Peptide Trajectories: Implications for Personalized Risk and Management

Dynamic C-peptide patterns during OGTT uncover metabolic heterogeneity in GDM, identifying insulin-resistant women at risk for fetal overgrowth and normoglycemic women at risk for preeclampsia, suggesting improved stratified treatment beyond glucose-based diagnosis.
Telephone-Based Weight Loss Intervention Enhances Outcomes in Women With Stage II/III Breast Cancer: Insights From the BWEL Trial and Complementary Studies

Telephone-Based Weight Loss Intervention Enhances Outcomes in Women With Stage II/III Breast Cancer: Insights From the BWEL Trial and Complementary Studies

A phase 3 trial demonstrates that a telephone-based lifestyle intervention achieves clinically significant weight loss in women with stage II/III breast cancer and overweight/obesity, with notable effectiveness across demographics, especially in postmenopausal women.
Prenatal Exposure to Chlorpyrifos and Its Long-Term Impact on Brain Development and Motor Function in Children: Evidence from Imaging and Cohort Studies

Prenatal Exposure to Chlorpyrifos and Its Long-Term Impact on Brain Development and Motor Function in Children: Evidence from Imaging and Cohort Studies

Elevated prenatal chlorpyrifos exposure is linked to widespread brain structural abnormalities, reduced neuronal density, and impaired motor functions in children, underscoring the need for exposure minimization during pregnancy.
Drivers of Human Papillomavirus Vaccine Uptake in Migrant Populations and Interventions to Improve Coverage

Drivers of Human Papillomavirus Vaccine Uptake in Migrant Populations and Interventions to Improve Coverage

This systematic review reveals multifaceted barriers to HPV vaccine uptake among migrants globally, with overall low coverage. It highlights individual, social, and systemic factors influencing uptake and delineates effective culturally tailored strategies to enhance vaccination rates and work towards cervical cancer elimination.