In Utero Embolization for Fetal Vein of Galen Malformation: Early Clinical Insights and Outcomes

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Vein of Galen malformation (VOGM) is a severe congenital cerebrovascular anomaly with high perinatal mortality and neurodevelopmental impairment risk, especially in fetuses exhibiting widened falcine sinus diameters. A novel, ultrasound-guided in utero embolization procedure targeting the prosencephalic venous varix demonstrated feasibility and potential clinical benefits in improving survival and neurodevelopmental outcomes. However, this intervention carries increased risk of unscheduled and preterm deliveries, which must be carefully balanced against its benefits.

Study Background and Disease Burden

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