Neurology – Page 14

Microbiome Virulence Signatures in the Oral-Gut-Brain Axis: New Insights into Parkinson’s Disease and Cognitive Decline

By MedXY 09/29/2025

This study reveals how virulence factors in oral and gut microbiomes and their translocation affect cognitive impairment in Parkinson’s disease, highlighting novel biomarker potential and the importance of the oral-gut-brain axis for early diagnosis and therapeutic strategies.

Clinical Updates Neurology news Specialties

Efficacy and Acceptability of Cognitive Behavioral Therapy for Insomnia in Chronic Disease: A Comprehensive Meta-Analysis

By MedXY 09/28/2025

This meta-analysis confirms that cognitive behavioral therapy for insomnia (CBT-I) is an effective, well-accepted treatment improving sleep outcomes across diverse chronic diseases, with minimal adverse effects and potential for broad clinical application.

Neurology news Specialties

Levodopa in Acute Stroke Rehabilitation: Insights from the ESTREL Randomized Clinical Trial

By MedXY 09/28/2025

The ESTREL trial demonstrates that levodopa added to standardized rehabilitation does not significantly improve motor recovery after acute stroke, challenging its adjunctive use for enhancing neuroplasticity in stroke rehabilitation.

Clinical Updates Neurology news

Clinically Meaningful Changes in Cognitive and Functional Measures Early in Alzheimer’s Disease: Insights from Population-Based Cohorts

By MedXY 09/28/2025

This review synthesizes evidence on clinically meaningful within-patient changes in cognitive and functional assessments among individuals transitioning to mild cognitive impairment (MCI), highlighting implications for clinical trials and early intervention in Alzheimer's disease and related dementias (ADRD).

Cardiology Clinical Updates Neurology news

Electrophysiological Study Surpasses ECG in Predicting Life-Threatening Conduction Delays in Myotonic Dystrophy Type 1

By MedXY 09/27/2025

In patients with myotonic dystrophy type 1 (DM1), electrophysiological study (EPS) using the His-ventricular (HV) interval is superior to electrocardiogram (ECG) in predicting major bradyarrhythmic events, suggesting enhanced risk stratification with EPS-guided thresholds.

General Surgery Neurology news

Efficacy and Safety of Shunt Surgery in Idiopathic Normal-Pressure Hydrocephalus: Insights from a Rigorous Randomized Controlled Trial

By MedXY 09/27/2025

A double-blind, placebo-controlled trial demonstrates that shunt surgery significantly improves gait velocity and balance in patients with idiopathic normal-pressure hydrocephalus who respond to temporary CSF drainage, with mixed safety outcomes and no cognitive or urinary symptom benefits at 3 months.

Clinical Updates Neurology news

Nexiguran Ziclumeran Gene Editing: A Pioneering Treatment for Hereditary ATTR with Polyneuropathy

By MedXY 09/26/2025

Nexiguran ziclumeran, an innovative CRISPR-Cas9 gene-editing therapy, demonstrates rapid, sustained suppression of transthyretin (TTR) in hereditary ATTR polyneuropathy patients, showing promising late-phase clinical safety and efficacy.

Family Medicine & Nutrition Neurology news Specialties

Circulating Nanoparticles and Carotenoids as Biomarkers of Rehabilitation Recovery in Parkinson’s Disease

By MedXY 09/26/2025

Intensive treadmill rehabilitation in Parkinson's disease alters the biochemical composition of circulating extracellular vesicle-like particles, particularly increasing carotenoid content, which correlates with improved gait parameters, highlighting a potential biomarker for monitoring rehabilitation efficacy.

Clinical Updates General Surgery Neurology news Specialties

Minimally Invasive Surgery versus Medical Management for Supratentorial Intracerebral Hemorrhage: Insights from the MIND Trial

By MedXY 09/26/2025

The MIND trial compared minimally invasive surgery using the Artemis device to standard medical management for supratentorial intracerebral hemorrhage, finding no significant improvement in 180-day functional outcomes or 30-day mortality with surgery.

General Surgery Neurology news Specialties

Minimally Invasive Surgery vs Medical Management in Supratentorial Intracerebral Hemorrhage: Insights from the MIND Randomized Trial

By MedXY 09/26/2025

The MIND trial found no significant functional benefit or mortality reduction with minimally invasive surgery compared to medical management alone in supratentorial intracerebral hemorrhage patients at 180 days.

Neurology news

Sustained Symptom Control over Five Years: Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson Disease

By MedXY 09/26/2025

Five-year follow-up from the INTREPID trial confirms that subthalamic nucleus deep brain stimulation significantly improves motor symptoms, reduces dyskinesia, lowers medication needs, and enhances daily living activities in moderate to advanced Parkinson disease patients, with an acceptable safety profile.

Clinical Updates Neurology news

Long-Term Safety and Effectiveness of Personalized Adaptive Deep Brain Stimulation in Parkinson’s Disease

By MedXY 09/26/2025

This international trial demonstrates that personalized adaptive deep brain stimulation (aDBS) is a safe, effective, and well-tolerated long-term therapy for Parkinson's disease patients previously stable on continuous DBS.

Clinical Updates Diabetes & Endocrinology Neurology news Specialties

Promising Links Between Diabetes Medications and Alzheimer’s Disease Risk Reduction

By MedXY 09/25/2025

Recent real-world data suggest GLP-1 receptor agonists and SGLT2 inhibitors may lower Alzheimer’s disease risk more effectively than DPP-4 inhibitors, highlighting the need for randomized trials to confirm potential neuroprotective benefits.

General Surgery Neurology Specialties

Hyperbaric Oxygen Therapy Enhances Recovery After Intracranial Aneurysm Surgery

By MedXY 09/25/2025

A meta-analysis of 11 RCTs involving over 2000 patients shows hyperbaric oxygen therapy significantly improves neurologic function, independence, and quality of life post-intracranial aneurysm surgery.

Clinical Updates Neurology Pediatrics Specialties

Modifiable Parental Factors Influence Adolescent Sleep

By MedXY 09/24/2025

This prospective cohort study identifies modifiable parental factors linked to adolescent sleep outcomes over 4 years, highlighting the mediating roles of screen use and emotional regulation and sex-specific effects, with implications for interventions targeting adolescent sleep health.

Clinical Updates Neurology news OB/GYN & Women's Health Specialties

Sleep Disorders in Pregnancy: Unveiling Their Impact on Ischemic Placental Disease and Severe Morbidity

By MedXY 09/24/2025

Pregnant individuals with insomnia or obstructive sleep apnea face significantly increased risks of ischemic placental disease, severe maternal morbidity, and preterm birth, highlighting the critical need for early detection and intervention.

Neurology news Specialties

Long-Term Outcomes in Critically Ill Adults With Acute Encephalitis: Insights From a Multicenter French Cohort

By MedXY 09/23/2025

A prospective study of 310 ICU patients with acute encephalitis reveals that half suffer moderate to severe disability or death at 3 months. Autoimmune encephalitis patients show notable recovery over one year, highlighting the need for tailored long-term support.

Clinical Updates Neurology OB/GYN & Women's Health

Intranasal Mesenchymal Stromal Cells for Perinatal Arterial Stroke: Promising Safety and Improved Neurodevelopment at Two Years

By MedXY 09/22/2025

The PASSIoN study shows that intranasally administered allogeneic mesenchymal stromal cells in neonates with perinatal arterial ischemic stroke are safe up to two years and suggest better motor outcomes compared to untreated cohorts.

Clinical Updates Neurology

RNS60 as Adjunctive Therapy in Acute Large Vessel Occlusion Stroke: Insights from the RESCUE Trial

By MedXY 09/22/2025

The RESCUE trial demonstrates that RNS60, a novel oxygen-supersaturated saline solution, is safe and reduces infarct growth when added to endovascular thrombectomy in acute ischemic stroke due to large vessel occlusion, supporting further investigation in larger studies.

Clinical Updates Neurology news

Safety and Efficacy of Perispinal Etanercept for Chronic Stroke: A Comprehensive Review of Clinical Trial Evidence

By MedXY 09/22/2025

Perispinal etanercept is safe but does not improve quality of life in chronic stroke patients, as demonstrated by a Class I randomized trial; translational implications and future research directions are discussed.