Internal Medicine – Page 7

Bexotegrast in Primary Sclerosing Cholangitis: Promising Safety and Pharmacodynamics from Phase II INTEGRIS-PSC Trial

By MedXY 10/28/2025

The Phase II INTEGRIS-PSC trial demonstrates that bexotegrast, a dual αvβ6/αvβ1 integrin inhibitor, is well tolerated in PSC patients with liver fibrosis and shows potential to attenuate fibrotic progression, supporting integrin-targeted therapy as a novel approach.

Gastroenterology Internal Medicine news

Long-Term Real-World Effectiveness, Safety, and Liver Stiffness Changes with Obeticholic Acid in Primary Biliary Cholangitis

By MedXY 10/28/2025

This study confirms the sustained effectiveness and safety of obeticholic acid (OCA) in primary biliary cholangitis (PBC) over a 2-year median follow-up, highlighting its impact on liver stiffness and fibrosis progression, especially in biochemical responders.

Infectious Diseases Internal Medicine news

Targeting HBx-Induced HSPB1: A Novel Approach to Combat Chronic Hepatitis B and Boost Liver Immunity

By MedXY 10/27/2025

This review explores the potential of targeting HBx-induced HSPB1 to suppress HBV cccDNA and enhance hepatic immune responses, highlighting a promising peptide-based therapeutic approach.

Internal Medicine Neurology news

Emerging Role of GLP-1 and GIP/GLP-1 Receptor Agonists in Managing Idiopathic Intracranial Hypertension

By MedXY 10/27/2025

This review analyzes current evidence supporting the use of GLP-1 and GIP/GLP-1 receptor agonists in IIH, highlighting benefits in reducing papilledema, visual disturbances, and headaches.

Cardiology Internal Medicine news

The Hidden Cardiovascular Risks of Anabolic Steroid Abuse in Men and Women: Insights from a Danish Study

By MedXY 10/27/2025

This study highlights the association between illicit anabolic steroid use and adverse cardiovascular outcomes in both sexes, emphasizing the need for preventive strategies in recreational sports.

Internal Medicine news

Comparative Effectiveness and Costs of Bariatric Surgery Versus GLP-1 Receptor Agonists in Obesity Management

By MedXY 10/27/2025

This article reviews recent evidence comparing weight loss outcomes and healthcare costs of bariatric surgery and GLP-1 receptor agonists, highlighting implications for clinical decision-making in treating class II and III obesity.

Internal Medicine news Oncology Transplantation

Balancing Efficacy and Safety: Immune Checkpoint Inhibitors in Solid Organ Transplant Recipients with Advanced Cancers

By MedXY 10/27/2025

This systematic review and meta-analysis evaluate cancer and graft outcomes in transplant recipients treated with immune checkpoint inhibitors, revealing differences by cancer type and potential strategies to reduce rejection risk.

Internal Medicine news Rheumatology

Emerging Promise of Telitacicept in Treating Systemic Lupus Erythematosus: Insights from a Phase 3 Trial

By MedXY 10/25/2025

This article reviews a pivotal phase 3 trial demonstrating telitacicept's efficacy and safety in active SLE, highlighting its potential as a novel targeted therapy.

Cardiology Internal Medicine Rehabilitation Medicine

Integrating Obesity Management into Cardiac Rehabilitation: Challenges, Evidence, and Future Directions

By MedXY 10/24/2025

Obesity management in cardiac rehabilitation (CR) is underutilized despite its cardiovascular benefits. This review explores the evidence, complexities, patient perspectives, and healthcare provider attitudes, emphasizing tailored strategies to optimize care within CR programs.

AI Cardiology Internal Medicine news Rehabilitation Medicine

Revolutionizing Cardiac Rehab: The Impact of Wearable Technology and Online Coaching

By MedXY 10/24/2025

This review discusses a landmark study demonstrating how wearable devices and online coaching improve exercise capacity in coronary artery disease patients, highlighting advancements in remote cardiac rehabilitation.

Diabetes & Endocrinology HIV/AIDS Internal Medicine Specialties

Nucleoside Reverse Transcriptase Inhibitors: A Novel Therapeutic Avenue Against Inflammaging and Age-Related Diseases

By MedXY 10/22/2025

NRTIs, traditionally used in HIV and HBV treatment, demonstrate promising anti-inflammatory effects that may reduce the incidence of age-related diseases by inhibiting inflammaging processes associated with endogenous retroelements.

Internal Medicine Oncology Specialties

Evaluating Methylphenidate for Fatigue Management in Advanced Cancer: Insights from the MePFAC Randomized Controlled Trial

By MedXY 10/21/2025

The MePFAC trial demonstrates that methylphenidate is safe but does not significantly reduce fatigue compared to placebo in advanced cancer patients receiving palliative care, challenging previous assumptions about its efficacy.

Internal Medicine Psychiatry Specialties

Single-Dose MM120 (Lysergide) Shows Promise in Treating Generalized Anxiety Disorder: Phase 2b RCT Results

By MedXY 10/21/2025

A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.

Internal Medicine Neurology news

Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults

By MedXY 10/20/2025

This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.

Internal Medicine news Public Health

Optimizing Healthy Ageing: The Impact of Physical Activity and Sedentary Behavior on Intrinsic Capacity in Older Adults

By MedXY 10/20/2025

This prospective Spanish cohort study reveals that moderate-to-vigorous physical activity enhances intrinsic capacity in older adults, while sedentary behavior impairs it, underscoring the role of active lifestyles in promoting healthy ageing.

Internal Medicine Public Health Specialties

Unraveling the Hidden and Measured Drivers of Chronic Disease Accumulation Across Organ Systems

By MedXY 10/20/2025

A 30-year birth cohort study reveals that life-course factors, especially modifiable markers like BMI, blood glucose, and blood pressure, significantly influence the buildup of chronic diseases across eight organ systems, yet much remains unexplained, prompting further research.

Internal Medicine news Public Health

Global Mortality Trends 1990-2023: Insights from the GBD 2023 Study on Causes of Death

By MedXY 10/20/2025

The GBD 2023 Study integrates data from 204 countries to reveal shifting global mortality patterns, emphasizing the impact of COVID-19, declining vaccine-preventable deaths, and rising non-communicable diseases, highlighting critical areas for targeted public health action.

Internal Medicine news Public Health

Extending the Hospital Frailty Risk Score to All Adults: Implications for Hospital Stay, Mortality, and Costs in England

By MedXY 10/20/2025

The Hospital Frailty Risk Score (HFRS) predicts length of stay, mortality, and costs across all adult age groups in England, with stronger effects in older adults, supporting broader clinical use beyond the elderly.

Internal Medicine Neurology news

Unraveling Blood-Based Biomarkers in Neurodegenerative Diseases: Insights from the Young Finns Study on Intergenerational and Metabolic Influences

By MedXY 10/20/2025

This cohort study from the Young Finns Study elucidates factors influencing blood-based biomarkers for neurodegenerative diseases, highlighting age, APOE ε4 genotype, kidney function, metabolic parameters, and notable intergenerational associations.

Internal Medicine news Public Health Specialties

Enhancing Quality of Life in Older Cancer Patients: The Impact of Comprehensive Geriatric Assessment and Patient Coaching

By MedXY 10/20/2025

The G-oncoCOACH trial demonstrates that comprehensive geriatric assessment combined with geriatric team implementation and extensive patient coaching significantly improves quality of life in older patients with solid tumors undergoing systemic therapy.