Internal Medicine

Nucleoside Reverse Transcriptase Inhibitors: A Novel Therapeutic Avenue Against Inflammaging and Age-Related Diseases

By MedXY 10/22/2025

NRTIs, traditionally used in HIV and HBV treatment, demonstrate promising anti-inflammatory effects that may reduce the incidence of age-related diseases by inhibiting inflammaging processes associated with endogenous retroelements.

Internal Medicine Oncology Specialties

Evaluating Methylphenidate for Fatigue Management in Advanced Cancer: Insights from the MePFAC Randomized Controlled Trial

By MedXY 10/21/2025

The MePFAC trial demonstrates that methylphenidate is safe but does not significantly reduce fatigue compared to placebo in advanced cancer patients receiving palliative care, challenging previous assumptions about its efficacy.

Internal Medicine Psychiatry Specialties

Single-Dose MM120 (Lysergide) Shows Promise in Treating Generalized Anxiety Disorder: Phase 2b RCT Results

By MedXY 10/21/2025

A phase 2b trial reveals that single doses of MM120 produce dose-dependent reductions in anxiety symptoms in adults with moderate to severe generalized anxiety disorder, paving the way for phase 3 studies.

Internal Medicine Neurology news

Blood Biomarkers of Alzheimer’s Disease Predict Long-Term Muscle Strength Decline in Older Adults

By MedXY 10/20/2025

This study links Alzheimer’s disease-related blood biomarkers with accelerated muscle strength loss over 12 years, highlighting the interplay between neurodegeneration and physical decline in aging populations.

Internal Medicine news Public Health

Optimizing Healthy Ageing: The Impact of Physical Activity and Sedentary Behavior on Intrinsic Capacity in Older Adults

By MedXY 10/20/2025

This prospective Spanish cohort study reveals that moderate-to-vigorous physical activity enhances intrinsic capacity in older adults, while sedentary behavior impairs it, underscoring the role of active lifestyles in promoting healthy ageing.

Internal Medicine Public Health Specialties

Unraveling the Hidden and Measured Drivers of Chronic Disease Accumulation Across Organ Systems

By MedXY 10/20/2025

A 30-year birth cohort study reveals that life-course factors, especially modifiable markers like BMI, blood glucose, and blood pressure, significantly influence the buildup of chronic diseases across eight organ systems, yet much remains unexplained, prompting further research.

Internal Medicine news Public Health

Global Mortality Trends 1990-2023: Insights from the GBD 2023 Study on Causes of Death

By MedXY 10/20/2025

The GBD 2023 Study integrates data from 204 countries to reveal shifting global mortality patterns, emphasizing the impact of COVID-19, declining vaccine-preventable deaths, and rising non-communicable diseases, highlighting critical areas for targeted public health action.

Internal Medicine news Public Health

Extending the Hospital Frailty Risk Score to All Adults: Implications for Hospital Stay, Mortality, and Costs in England

By MedXY 10/20/2025

The Hospital Frailty Risk Score (HFRS) predicts length of stay, mortality, and costs across all adult age groups in England, with stronger effects in older adults, supporting broader clinical use beyond the elderly.

Internal Medicine Neurology news

Unraveling Blood-Based Biomarkers in Neurodegenerative Diseases: Insights from the Young Finns Study on Intergenerational and Metabolic Influences

By MedXY 10/20/2025

This cohort study from the Young Finns Study elucidates factors influencing blood-based biomarkers for neurodegenerative diseases, highlighting age, APOE ε4 genotype, kidney function, metabolic parameters, and notable intergenerational associations.

Internal Medicine news Public Health Specialties

Enhancing Quality of Life in Older Cancer Patients: The Impact of Comprehensive Geriatric Assessment and Patient Coaching

By MedXY 10/20/2025

The G-oncoCOACH trial demonstrates that comprehensive geriatric assessment combined with geriatric team implementation and extensive patient coaching significantly improves quality of life in older patients with solid tumors undergoing systemic therapy.

Internal Medicine Public Health Specialties

Unveiling Frailty in England’s Homeless Population: Socioeconomic Insights and Health Implications

By MedXY 10/20/2025

A large-scale analysis reveals high frailty prevalence among people experiencing homelessness in England, highlighting critical socioeconomic factors influencing vulnerability.

Internal Medicine news

Integrating Exercise and Medication Management in Geriatric Care: A Holistic Approach to Improve Health Outcomes and Reduce Polypharmacy

By MedXY 10/20/2025

Integrating exercise prescriptions with medication management offers a holistic strategy to optimize health, reduce polypharmacy, and mitigate adverse effects in older adults, enhancing their functional status and quality of life.

Diabetes & Endocrinology Internal Medicine Specialties

Revisiting Obesity Classification: Insights from a Population-Based Survey in Peru Using New Clinical Frameworks

By MedXY 10/19/2025

This review examines a landmark Peruvian study applying new obesity definitions that incorporate clinical dysfunction and adiposity measures beyond BMI, revealing substantial underdiagnosis with traditional approaches and ethnic variation in fat distribution.

Gastroenterology Internal Medicine Specialties

Comparative Risks of MASLD and MetALD: Insights from a Comprehensive Meta-Analysis on Hepatic and Extrahepatic Outcomes

By MedXY 10/19/2025

This meta-analysis reveals that MetALD confers higher risks of liver-related events, hepatocellular carcinoma, and extrahepatic cancers compared to MASLD, while mortality and cardiovascular risks are similar, emphasizing tailored clinical approaches.

Internal Medicine Oncology Specialties

Real-World Insights into HER2-Positive Metastatic Breast Cancer Treatments: Comparing T-DXd, T-DM1, and Tucatinib

By MedXY 10/18/2025

This study uses real-world data to compare the effectiveness and safety of trastuzumab deruxtecan versus trastuzumab emtansine and tucatinib in HER2-positive metastatic breast cancer, confirming their clinical value.

Diabetes & Endocrinology Internal Medicine Specialties

Monlunabant Shows Promise for Weight Loss in Obesity and Metabolic Syndrome: A Phase 2A Trial Review

By MedXY 10/18/2025

This phase 2a trial demonstrates that monlunabant induces significant weight loss across various doses in obese adults with metabolic syndrome, with dose-dependent adverse events highlighting the need for further safety evaluation.

Internal Medicine Psychiatry Specialties

Comparative Effectiveness of Long-Acting Injectable Versus Oral Antipsychotics in Older Adults with Schizophrenia: Insights from Hong Kong’s Population-Based Study

By MedXY 10/18/2025

This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.

Infectious Diseases Internal Medicine news

Deciphering the Impact of Resistance Genes on Antibiotic Efficacy in E. coli: Insights from a Comprehensive Study

By MedXY 10/18/2025

This study quantifies how specific resistance genes influence minimum inhibitory concentrations in E. coli, enhancing prediction accuracy for antibiotic resistance.

AI Internal Medicine news

Navigating the AI Revolution in Health Care: Insights from the JAMA Summit

By MedXY 10/14/2025

Artificial intelligence is reshaping health care, offering vast potential benefits alongside significant challenges. The JAMA Summit emphasizes the need for robust evaluation, equitable deployment, and multi-stakeholder collaboration to ensure AI improves outcomes safely and fairly.

Internal Medicine Psychiatry

Lithium’s Role in Reducing Suicidal Ideation and Behaviors: An Updated Meta-Analysis of Randomized Controlled Trials

By MedXY 10/12/2025

This systematic review evaluates lithium’s efficacy in reducing suicidal ideation, attempts, and completed suicide, highlighting methodological challenges and the likelihood of benefit despite lack of statistical significance in RCTs.