Preserving Bone Quality in Older Adults with Obesity Through Lifestyle Intervention: Insights from the LIMB-Q Trial

Preserving Bone Quality in Older Adults with Obesity Through Lifestyle Intervention: Insights from the LIMB-Q Trial

The LIMB-Q trial demonstrates that intensive lifestyle interventions combining weight management and exercise preserve bone quality in older adults with obesity, despite significant weight loss, highlighting a promising approach for mitigating osteoporosis risk during aging.
Acute Angle Closure Incidence in a Large Countywide Safety Net Teleretinal Screening Program: Safety of Pharmacologic Dilation in Diabetic Retinopathy Screening

Acute Angle Closure Incidence in a Large Countywide Safety Net Teleretinal Screening Program: Safety of Pharmacologic Dilation in Diabetic Retinopathy Screening

This review synthesizes evidence on the incidence of acute angle closure (AAC) following pharmacologic pupillary dilation in a large teleretinal screening program, confirming the very low risk and supporting dilation safety in diverse populations.
Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Patients with Heart Failure: Prevalence, Genetics, and Clinical Implications

Transthyretin Cardiac Amyloidosis in Older Black and Hispanic Patients with Heart Failure: Prevalence, Genetics, and Clinical Implications

A prospective study reveals transthyretin cardiac amyloidosis (ATTR-CA) affects a significant proportion of older Black patients with heart failure, especially men over 75, with nearly half linked to the V142I genetic variant. Hispanic prevalence is lower but still notable.
Long-term Stroke Risk in Chinese Adults with Newly Diagnosed Diabetes and Impaired Glucose Tolerance: Insights from the 34-Year Da Qing Diabetes Study

Long-term Stroke Risk in Chinese Adults with Newly Diagnosed Diabetes and Impaired Glucose Tolerance: Insights from the 34-Year Da Qing Diabetes Study

A 34-year follow-up of the Da Qing Diabetes Study reveals significantly increased stroke incidence among Chinese adults with newly diagnosed type 2 diabetes and impaired glucose tolerance, highlighting the beneficial impact of lifestyle intervention, particularly in women.
Lobeglitazone as an Effective and Safe Addition to Metformin and Sitagliptin Therapy in Type 2 Diabetes: Results from a 52-Week Multicentre Phase III Trial

Lobeglitazone as an Effective and Safe Addition to Metformin and Sitagliptin Therapy in Type 2 Diabetes: Results from a 52-Week Multicentre Phase III Trial

This phase III trial showed that adding lobeglitazone to metformin and sitagliptin significantly improves glycaemic control and insulin sensitivity with favorable safety over 52 weeks in Korean patients with type 2 diabetes inadequately controlled by dual therapy.