Cardiology – Page 6

Win Ratio Analysis Confirms No Net Benefit for Anticoagulation in Device-Detected Atrial Fibrillation

By MedXY 01/03/2026

A hierarchical win ratio analysis of the NOAH-AFNET 6 trial confirms that edoxaban does not provide a net clinical benefit over no anticoagulation in patients with device-detected atrial fibrillation, primarily due to the balance between low stroke rates and significant bleeding risks.

Cardiology news Public Health

Timing Matters: Delayed Statin Initiation After Incidental High LDL-C Detection Significantly Increases Myocardial Infarction Risk

By MedXY 01/03/2026

A large-scale cohort study demonstrates that delaying statin therapy following the incidental discovery of high LDL-C during routine health screenings leads to a progressively higher risk of myocardial infarction, emphasizing the critical importance of early pharmacological intervention.

Cardiology news

Baseline Risk Does Not Resuscitate PCI Benefit in Ischemic Cardiomyopathy: Lessons from the REVIVED-BCIS2 Sub-analysis

By MedXY 01/03/2026

A prespecified analysis of the REVIVED-BCIS2 trial reveals that baseline risk of death or hospitalization does not modify the effectiveness of PCI in patients with ischemic left ventricular dysfunction, reinforcing the primacy of optimal medical therapy.

Cardiology news

The 30-Day Ischemic Penalty: Why Early Aspirin Withdrawal in ACS Requires Caution

By MedXY 01/03/2026

A landmark analysis from the NEOMINDSET trial demonstrates that while potent P2Y12 inhibitor monotherapy reduces bleeding, it significantly increases ischemic risk in the first 30 days after PCI for acute coronary syndrome, suggesting that the timing of aspirin withdrawal is critical for patient safety.

Cardiology Critical Care news

High-Acuity Presentations with Favorable Outcomes: The Paradox of Young Adults in the Cardiac ICU

By MedXY 01/03/2026

A large-scale registry study reveals that young adults (18-39) in the Cardiac Intensive Care Unit present with higher rates of cardiogenic shock and cardiac arrest compared to older adults, yet demonstrate significantly higher survival rates despite more intensive resource utilization.

Cardiology news

Subcutaneous ICDs in the Real World: Lessons from the French Nationwide HONEST Study

By MedXY 01/03/2026

The nationwide HONEST study provides critical five-year data on S-ICD performance, highlighting a 13.8% inappropriate shock rate, the protective effect of SMART Pass filtering, and unexpected challenges with battery longevity in a large, unselected patient population.

Cardiology news

M-TEER Benefits in Secondary Mitral Regurgitation: Consistent Clinical and Quality-of-Life Improvements Regardless of Baseline Health Status

By MedXY 01/03/2026

The RESHAPE-HF2 trial reveals that mitral transcatheter edge-to-edge repair (M-TEER) significantly reduces cardiovascular risks and enhances health status across all baseline patient conditions, reinforcing its role as a key intervention for symptomatic heart failure and secondary mitral regurgitation.

Cardiology news

Precision Risk Assessment in CPVT: New Validated Models Predict Arrhythmic Events on Beta-Blocker Therapy

By MedXY 01/03/2026

A landmark study has developed and validated the first clinical risk prediction models for RYR2-mediated CPVT, identifying key factors like age at treatment and prior symptoms that determine life-threatening outcomes despite beta-blocker therapy.

Cardiology news

FFR-Guided Revascularization Significantly Reduces 12-Month MACCE in TAVI Patients: The FAITAVI Trial

By MedXY 01/03/2026

The FAITAVI trial demonstrates that physiology-guided PCI using FFR significantly reduces major adverse cardiac events, particularly mortality, compared to angiography-guided PCI in elderly patients undergoing TAVI with intermediate coronary lesions.

Cardiology Emergency Medicine news

Hypertensive Response in Advanced Conduction Disorders: A Paradoxical Marker of Haemodynamic Resilience?

By MedXY 01/03/2026

Recent research reveals that nearly half of patients with high-degree AV block present with hypertension, a phenotype characterized by preserved cardiac function and higher peripheral vascular resistance, leading to better short-term clinical outcomes compared to normotensive or unstable patients.

Cardiology news

Beyond the Mutation: Uncovering the Triggers of Disease Onset in Titin-Related Dilated Cardiomyopathy

By MedXY 01/03/2026

An international multicenter study reveals that while Titin-truncating variants significantly increase cardiomyopathy risk, disease onset is heavily influenced by male sex, co-morbidities, and atrial fibrillation, while early prophylactic therapy may offer substantial protection.

$Bailout Catheter Ablation: A Lifesaving Strategy for Refractory Ventricular Tachycardia in Early Acute Myocardial Infarction$

Cardiology Critical Care news

Bailout Catheter Ablation: A Lifesaving Strategy for Refractory Ventricular Tachycardia in Early Acute Myocardial Infarction

By MedXY 01/03/2026

A clinical study demonstrates that catheter ablation is a highly effective rescue therapy for refractory, scar-related ventricular tachycardia occurring in the early phase of acute myocardial infarction, challenging traditional management timelines.

Cardiology news

Beyond Arrhythmia: High-Risk Genotypes in Dilated Cardiomyopathy Predict Progression to Advanced Heart Failure

By MedXY 01/03/2026

A landmark Spanish study reveals that patients with 'arrhythmic' genotypes in dilated cardiomyopathy face a significantly higher risk of advanced heart failure events, including heart transplantation and VAD implantation, necessitating a paradigm shift in clinical management.

Cardiology news Pediatrics

Why Universal Cholesterol Screening for Familial Hypercholesterolaemia Should Wait Until Age One

By MedXY 01/03/2026

A landmark Norwegian study reveals that umbilical cord LDL-C levels overlap significantly between FH and non-FH newborns, making birth screening unreliable. In contrast, LDL-C becomes highly discriminative after age one, suggesting that universal screening should be deferred to early childhood.

Cardiology Emergency Medicine news

The Price of Time: 20-Year Study Reveals Pre-Hospital Delay as a Critical Driver of STEMI Mortality

By MedXY 01/03/2026

A 20-year analysis of 89,155 patients from the SWEDEHEART registry confirms that pre-hospital delay independently predicts short- and long-term mortality. Despite advances in reperfusion, women, elderly patients, and those with diabetes consistently experience significantly longer delays, highlighting a critical need for targeted public health interventions.

Cardiology news Radiology

Why the Parasternal Window May Be the New Gold Standard for Aortic Regurgitation Quantitation

By MedXY 01/03/2026

A landmark study demonstrates that measuring flow convergence from the parasternal long-axis window significantly outperforms apical PISA in feasibility and matches Cardiac MRI accuracy for assessing aortic regurgitation severity.

Cardiology news

JCAD Predicts Adverse Cardiovascular Events in ACS Patients with High Residual Risk

By MedXY 01/03/2026

A breakthrough study identifies the junctional protein associated with coronary artery disease (JCAD) as a significant predictor of recurrent cardiovascular events in ACS patients, particularly those with residual lipid and inflammatory risk, by modulating coagulation and fibrinolysis pathways.

Cardiology news

Beyond the Resting State: Why Exercise Pulmonary Vascular Resistance is the New Gold Standard for Fontan Prognosis

By MedXY 01/03/2026

Groundbreaking research demonstrates that exercise-induced pulmonary vascular resistance, rather than resting measurements, is a critical predictor of mortality in Fontan patients, supported by new non-invasive diagnostic algorithms for clinical practice.

Cardiology Critical Care news

The PERT Revolution: Rising Catheter-Directed Therapy Adoption Correlates with Improved Pulmonary Embolism Outcomes

By MedXY 01/02/2026

A multicenter registry study reveals that Pulmonary Embolism Response Teams (PERT) are increasingly utilizing catheter-directed therapies, particularly mechanical thrombectomy, leading to significantly lower in-hospital mortality and shorter hospital stays compared to national averages.

Cardiology Critical Care news

Restoring the Beat: How ERRγ Agonism Reverses Cardiomyocyte Subtype Conversion in Sepsis-Induced Cardiomyopathy

By MedXY 01/02/2026

This study identifies oestrogen-related receptor γ (ERRγ) as a master regulator of cardiomyocyte phenotypic transitions during sepsis, offering a novel therapeutic target to restore cardiac function and improve survival in sepsis-induced cardiomyopathy.