Surgical Management of Left-Sided Infective Endocarditis: Insights from the Nationwide NIDUS Registry

Surgical Management of Left-Sided Infective Endocarditis: Insights from the Nationwide NIDUS Registry

A nationwide Danish study reveals that while 40% of left-sided infective endocarditis patients have surgical indications, only half undergo surgery. Those receiving surgery are younger, less comorbid, and show improved survival, underscoring the need for refined risk assessment in high-risk cases.
Targeted Reduction of Sitting Time Versus Increased Sit-to-Stand Transitions: Effects on Blood Pressure and Glucose Regulation in Postmenopausal Women

Targeted Reduction of Sitting Time Versus Increased Sit-to-Stand Transitions: Effects on Blood Pressure and Glucose Regulation in Postmenopausal Women

A 3-month randomized trial in overweight postmenopausal women found that increasing sit-to-stand transitions significantly reduces diastolic blood pressure, while reducing total sitting time alone does not improve blood pressure or glucoregulatory measures.
Sacubitril-Valsartan for Cardiac Protection During Breast Cancer Therapy: Insights from the PRADA II Trial

Sacubitril-Valsartan for Cardiac Protection During Breast Cancer Therapy: Insights from the PRADA II Trial

The PRADA II trial evaluated sacubitril-valsartan for preventing cardiac dysfunction during anthracycline-based breast cancer therapy. While it did not significantly preserve left ventricular ejection fraction, improvements in myocardial strain and cardiac biomarkers suggest a potential role in cardioprotection.