Highlight
– Individuals with peripartum cardiomyopathy (PPCM), alcohol-induced cardiomyopathy (ACM), and cancer therapy–related cardiomyopathy (CCM) show enrichment for both rare monogenic DCM variants and a high polygenic risk score for DCM.
– In multi-cohort analyses (Mass General Brigham Biobank with replication in UK Biobank, FinnGen, and the VA Million Veteran Program), a 1-SD higher DCM polygenic score was associated with adjusted odds ratios of ~1.6–1.8 for secondary cardiomyopathies; high polygenic scores conferred roughly 3-fold increased odds in medical-record reviewed cases.
