Medxy AI – Page 73

PROMOTE Study Validates Algorithm for Conduction Disturbance Management After TAVR

By MedXY 12/17/2025

A prospective multicenter study confirms that a prespecified algorithm for conduction disturbance management after TAVR is safe, with low sudden cardiac death risk but persistent high pacemaker rates.

Cardiology news

Distinct Mechanisms Drive Early and Delayed Heart Block After TAVR: Insights from Boston Cohort Study

By MedXY 12/17/2025

Prospective cohort study reveals AV nodal versus infranodal conduction patterns underpinning timing of heart block after TAVR.

news Orthopedics

Cryotherapy After Total Knee Replacement: Limited Evidence for Modest Benefits

By MedXY 12/16/2025

Low-certainty evidence suggests cryotherapy may slightly reduce blood loss, pain, and swelling after total knee replacement, but clinical relevance remains uncertain.

Critical Care news Pediatrics

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials

By MedXY 12/16/2025

Recent trials and meta-analyses challenge assumptions about optimal initial oxygen levels for preterm resuscitation.

news Oncology

Broad Genetic Testing Reveals Hidden Breast Cancer Risk in Women Without Family History

By MedXY 12/16/2025

The WISDOM trial found that 3.1% of women without breast cancer carried pathogenic variants in key susceptibility genes, many outside existing testing guidelines.

news OB/GYN & Women's Health

Progestagens Show Moderate Efficacy for Endometriosis Pain, But Evidence Variability Limits Clinical Certainty

By MedXY 12/16/2025

Oral progestagens reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal therapies remain uncertain.

news OB/GYN & Women's Health Oncology

Simple vs Radical Hysterectomy: Balancing Survival Outcomes and Quality of Life in Early Cervical Cancer

By MedXY 12/16/2025

Evidence suggests simple hysterectomy with pelvic lymphadenectomy may offer similar survival outcomes to radical hysterectomy in early-stage cervical cancer, with fewer adverse events and better short-term quality of life.

news OB/GYN & Women's Health Pediatrics

Immediate and Early Skin-to-Skin Contact After Birth: What the 2025 Cochrane Update Means for Practice

By MedXY 12/16/2025

A clear, evidence-based summary of the 2025 Cochrane review on immediate/early skin-to-skin contact (SSC), its impact on breastfeeding and newborn physiology, gaps in maternal outcomes, and practical recommendations for clinical implementation.

Cardiology Internal Medicine news

Riboflavin and Blood Pressure: Evidence Remains Uncertain Despite Genetic Promise

By MedXY 12/16/2025

Cochrane review shows uncertain effects of riboflavin on blood pressure, highlighting a need for larger and better-quality trials.

Neurology news Pediatrics

Limited Evidence for Behavioural and Service Delivery Interventions in Childhood Epilepsy: Urgent Need for Robust Trials

By MedXY 12/16/2025

Current evidence for behavioural and service delivery interventions in childhood epilepsy is scarce and of low quality, highlighting an urgent need for rigorous, long-term trials.

Cardiology Neurology news

Low-Dose Colchicine Reduces Myocardial Infarction and Stroke Risk in Cardiovascular Disease Patients

By MedXY 12/16/2025

A large meta-analysis shows colchicine can lower MI and stroke risk without raising serious adverse events, but GI side effects remain a concern.

General Surgery news OB/GYN & Women's Health Oncology

Breast Surgery in Metastatic Breast Cancer: Local Control Without Survival Benefit

By MedXY 12/16/2025

Randomised trials show breast surgery improves local disease control but not overall survival in de novo metastatic breast cancer.

Infectious Diseases news OB/GYN & Women's Health Public Health

HPV Vaccination Significantly Reduces Precancerous Lesions and Anogenital Warts: Evidence from a Network Meta‑Analysis

By MedXY 12/16/2025

A large network meta‑analysis confirms HPV vaccines effectively reduce CIN2+ and anogenital warts, with no major safety concerns.

news Oncology

Postmenopausal Hormone Therapy: Balancing Endometrial Protection and Cancer Risk

By MedXY 12/16/2025

Updated evidence shows unopposed estrogen increases endometrial hyperplasia risk, while combined regimens offer better protection.

Cardiology news

Long-Term Hormone Therapy in Menopausal Women: Balancing Benefits and Risks

By MedXY 12/16/2025

Updated Cochrane review shows mixed outcomes for long-term hormone therapy in peri- and postmenopausal women.

news Urology

Physical Therapies Show Promise in Treating Urinary Incontinence in Older Women, But Evidence Remains Weak

By MedXY 12/16/2025

Network meta-analysis suggests physical therapies may outperform drugs in managing urinary incontinence in women over 60, but certainty is low.

news Oncology

Trastuzumab Deruxtecan plus Pertuzumab Becomes First-Line Standard for HER2‑Positive Metastatic Breast Cancer: Clinical Implications of the DESTINY‑Breast09 Approval

By MedXY 12/16/2025

The FDA has approved trastuzumab deruxtecan with pertuzumab as first-line therapy for unresectable or metastatic HER2‑positive breast cancer after DESTINY‑Breast09 showed a large PFS benefit versus standard THP; safety and maintenance strategy questions remain.

news Oncology Psychiatry

CBT‑I in Cancer Survivors: Small Subjective Gains, Unclear Objective Benefits — What the 2025 Cochrane Review Tells Clinicians

By MedXY 12/16/2025

A 2025 Cochrane review of 21 RCTs (2431 participants) finds cognitive behavioural therapy for insomnia (CBT‑I) yields modest improvements in self‑reported insomnia and sleep quality in people with cancer versus inactive controls or aerobic activity; objective sleep changes and long‑term effects remain uncertain.

Clinical Updates Family Medicine & Nutrition news OB/GYN & Women's Health

Calcium Supplementation During Pregnancy for Preventing Hypertensive Disorders: Current Evidence and Clinical Implications

By MedXY 12/16/2025

This review synthesizes recent randomized controlled trials and meta-analyses on calcium supplementation during pregnancy, evaluating its effectiveness in preventing hypertensive disorders such as pre-eclampsia and related maternal and neonatal outcomes.

Gastroenterology news Oncology

Intraperitoneal Chemotherapy for Gastric Cancer: Promising Survival Signals but Very Low‑Certainty Evidence

By MedXY 12/16/2025

A Cochrane review of nine RCTs (829 patients) found low‑certainty signals that intraperitoneal chemotherapy (mainly HIPEC) may improve overall survival in high‑risk and metastatic gastric cancer, but evidence is very uncertain due to bias, imprecision, and limited safety and QOL data.

PROMOTE Study Validates Algorithm for Conduction Disturbance Management After TAVR

Distinct Mechanisms Drive Early and Delayed Heart Block After TAVR: Insights from Boston Cohort Study

Cryotherapy After Total Knee Replacement: Limited Evidence for Modest Benefits

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials

Broad Genetic Testing Reveals Hidden Breast Cancer Risk in Women Without Family History

Progestagens Show Moderate Efficacy for Endometriosis Pain, But Evidence Variability Limits Clinical Certainty

Simple vs Radical Hysterectomy: Balancing Survival Outcomes and Quality of Life in Early Cervical Cancer

Immediate and Early Skin-to-Skin Contact After Birth: What the 2025 Cochrane Update Means for Practice

Riboflavin and Blood Pressure: Evidence Remains Uncertain Despite Genetic Promise

Limited Evidence for Behavioural and Service Delivery Interventions in Childhood Epilepsy: Urgent Need for Robust Trials

Low-Dose Colchicine Reduces Myocardial Infarction and Stroke Risk in Cardiovascular Disease Patients

Breast Surgery in Metastatic Breast Cancer: Local Control Without Survival Benefit

HPV Vaccination Significantly Reduces Precancerous Lesions and Anogenital Warts: Evidence from a Network Meta‑Analysis

Postmenopausal Hormone Therapy: Balancing Endometrial Protection and Cancer Risk

Long-Term Hormone Therapy in Menopausal Women: Balancing Benefits and Risks

Physical Therapies Show Promise in Treating Urinary Incontinence in Older Women, But Evidence Remains Weak

Trastuzumab Deruxtecan plus Pertuzumab Becomes First-Line Standard for HER2‑Positive Metastatic Breast Cancer: Clinical Implications of the DESTINY‑Breast09 Approval

CBT‑I in Cancer Survivors: Small Subjective Gains, Unclear Objective Benefits — What the 2025 Cochrane Review Tells Clinicians

Calcium Supplementation During Pregnancy for Preventing Hypertensive Disorders: Current Evidence and Clinical Implications

Intraperitoneal Chemotherapy for Gastric Cancer: Promising Survival Signals but Very Low‑Certainty Evidence

Predicting Ocular Relapse in Sarcoid Uveitis: Macular Edema and Baseline Inflammation as Critical Prognostic Markers

Liquid Biopsy Predicts Recurrence in HPV-Independent Head and Neck Cancer Months Before Imaging

In-Lab vs. At-Home Sleep Studies: Determining Minimum Recording Time and the Role of Positional Sleep Apnea

Navigating the Adhesion Maze: How Previous Abdominal Surgeries Impact Bariatric Outcomes