Neuropsychiatric Interaction with Vascular Health: Deciphering the Moderating Role of PTSD in Hormonal Contraceptive-Associated Cardiovascular Risk
Posted inClinical Updates Neurology news Psychiatry

Neuropsychiatric Interaction with Vascular Health: Deciphering the Moderating Role of PTSD in Hormonal Contraceptive-Associated Cardiovascular Risk

A large-scale cohort study demonstrates that while hormonal contraceptives are generally associated with lower cardiovascular risk in women, this protective effect is lost in those with PTSD, highlighting a critical intersection between psychiatric health and reproductive medicine.
Digital Phenotyping in Insomnia: Real-Time Smartphone Assessment Detects Daytime Benefits of Suvorexant Missed by Traditional Scales
Posted inNeurology news Psychiatry

Digital Phenotyping in Insomnia: Real-Time Smartphone Assessment Detects Daytime Benefits of Suvorexant Missed by Traditional Scales

A randomized clinical trial demonstrates that smartphone-based ecological momentary assessment (EMA) is significantly more sensitive than retrospective questionnaires in detecting the daytime clinical benefits of suvorexant, particularly regarding fatigue and subjective cognition in older adults with chronic insomnia.
Triple-Drug Regimen with Tiragolumab and Atezolizumab Shows Superior Response in First-Line Esophageal Cancer: The MORPHEUS-EC Trial
Posted inGastroenterology news Oncology

Triple-Drug Regimen with Tiragolumab and Atezolizumab Shows Superior Response in First-Line Esophageal Cancer: The MORPHEUS-EC Trial

The phase 1b/2 MORPHEUS-EC trial demonstrates that adding the anti-TIGIT antibody tiragolumab to atezolizumab and chemotherapy significantly improves objective response rates (67.7%) in patients with previously untreated, locally advanced or metastatic esophageal cancer, providing a promising new therapeutic strategy.
Distinct Neuroimaging Signatures: Atrial Fibrillation and Atherosclerosis Drive Divergent Vascular Brain Lesion Patterns
Posted inCardiology Neurology news

Distinct Neuroimaging Signatures: Atrial Fibrillation and Atherosclerosis Drive Divergent Vascular Brain Lesion Patterns

A large-scale comparative study of 3,508 patients reveals that atrial fibrillation and atherosclerosis produce significantly different vascular brain lesions on MRI, with AF favoring non-lacunar infarcts and periventricular white matter changes, while atherosclerosis is linked to lacunar infarcts and micro-bleeds.
Low Potassium Levels Linked to Five-Fold Increase in Daily Atrial Fibrillation Risk: Insights from Continuous Monitoring
Posted inCardiology Internal Medicine news

Low Potassium Levels Linked to Five-Fold Increase in Daily Atrial Fibrillation Risk: Insights from Continuous Monitoring

A post hoc analysis of the LOOP study reveals that hypokalaemia is significantly associated with an increased risk of daily atrial fibrillation, particularly longer episodes. The study highlights that deviations from a patient's individual baseline potassium level are stronger predictors of AF than absolute values.
Lowering Blood Pressure in Isolated Diastolic Hypertension: Evidence Supports Risk Reduction Across All Diastolic Levels
Posted inCardiology Internal Medicine news

Lowering Blood Pressure in Isolated Diastolic Hypertension: Evidence Supports Risk Reduction Across All Diastolic Levels

A large-scale meta-analysis reveals that lowering blood pressure in patients with isolated diastolic hypertension (IDH) provides cardiovascular protection comparable to those with systolic elevations, suggesting that diastolic thresholds alone should not preclude treatment in high-risk individuals.