Medxy AI – Page 120

Tailoring Systemic Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Evidence by Disease Volume and Timing of Metastasis

By MedXY 12/17/2025

A living network meta-analysis refines treatment strategies for mHSPC subgroups, favoring triplet therapy in synchronous high-volume cases and ARPI doublet therapy in others.

news Radiology Urology

Five-Year Safety of Avoiding Biopsy After Negative MRI in Prostate Cancer Pathways

By MedXY 12/17/2025

Long-term data show RAPID MRI-directed pathway safely avoids unnecessary biopsies while maintaining low rates of clinically significant prostate cancer.

news Oncology Urology

Refining Prostate Cancer Risk Prediction in Men of African Ancestry: Integrating Pathogenic Variants, Polygenic Scores, and Family History

By MedXY 12/17/2025

This study identifies key germline variants and demonstrates how combining genetic data with family history improves personalized prostate cancer risk assessment in men of African ancestry, guiding future screening strategies.

news Oncology

Personalizing Breast Cancer Screening: Insights from the WISDOM Trial on Risk-Based vs Annual Mammography

By MedXY 12/17/2025

The WISDOM trial shows risk-based breast cancer screening using genetic and clinical data as a safe alternative to annual mammography, tailoring screening frequency by individual risk without increasing advanced cancer rates.

Cardiology Infectious Diseases news

Prophylactic Strategies to Prevent Infection in Lower Limb Peripheral Arterial Reconstruction: Evidence and Clinical Implications

By MedXY 12/17/2025

Cochrane review shows prophylactic antibiotics may reduce SSI risk in peripheral arterial reconstruction; closed incision negative pressure therapy offers possible benefit but evidence is low.

Neurology news Oncology

Chemoendocrine Therapy Linked to Greater Cognitive Decline in Breast Cancer Patients, Regardless of Menopausal Status

By MedXY 12/17/2025

A secondary analysis of the RxPONDER trial finds chemoendocrine therapy causes more lasting cognitive impairment than endocrine therapy alone in both pre- and postmenopausal women.

news Otorhinolaryngology Respiratory

Biofeedback vs Respiratory Retraining: No Significant Difference in Inducible Laryngeal Obstruction Relief

By MedXY 12/17/2025

A pilot trial finds biofeedback and respiratory retraining equally effective for inducible laryngeal obstruction, offering clinicians flexible, patient-tailored options.

Neurology news Psychiatry

Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology

By MedXY 12/17/2025

A PET imaging study reveals increased frontal serotonin release in schizophrenia, particularly in deficit type, tied to worse negative symptoms.

Cardiology Neurology news

Combined Cardiorespiratory and Resistance Training After Stroke: Small Gains, Big Questions

By MedXY 12/17/2025

Evidence suggests combined aerobic and strength training post-stroke yields modest improvements in fitness and function but uncertain long-term benefits.

Neurology news

Do Behavioural, Self-Management, and Service Delivery Models Improve Outcomes in Adults with Epilepsy?

By MedXY 12/17/2025

A Cochrane review finds limited and low- to moderate-certainty evidence that behavioural, self-management, or service delivery interventions improve seizure control or quality of life in adults with epilepsy.

Diabetes & Endocrinology Neurology news

Omega-3 Fatty Acids Show Limited Benefits for Diabetic Peripheral Neuropathy

By MedXY 12/17/2025

Current evidence suggests minimal impact of omega-3 supplementation on neuropathy symptoms or quality of life in adults with diabetes.

news

Progestagens Show Promise for Pain Relief in Endometriosis, With Nuanced Efficacy Across Comparators

By MedXY 12/17/2025

Oral progestagens likely reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal treatments remain uncertain.

Cardiology news

Rare but High-Risk: New-Onset RBBB After TAVR Strongly Linked to Pacemaker Need

By MedXY 12/17/2025

New-onset right bundle branch block after TAVR is rare but carries a high risk of requiring permanent pacing within one week.

Cardiology news

Prophylactic Pacemakers After TAVR: Low Pacing Burden Raises Questions on Routine Use

By MedXY 12/17/2025

One-fourth of TAVR patients receive prophylactic pacemakers, but most have minimal pacing needs at 30 days.

Cardiology news

PROMOTE Study Validates Algorithm for Conduction Disturbance Management After TAVR

By MedXY 12/17/2025

A prospective multicenter study confirms that a prespecified algorithm for conduction disturbance management after TAVR is safe, with low sudden cardiac death risk but persistent high pacemaker rates.

Cardiology news

Distinct Mechanisms Drive Early and Delayed Heart Block After TAVR: Insights from Boston Cohort Study

By MedXY 12/17/2025

Prospective cohort study reveals AV nodal versus infranodal conduction patterns underpinning timing of heart block after TAVR.

news Orthopedics

Cryotherapy After Total Knee Replacement: Limited Evidence for Modest Benefits

By MedXY 12/16/2025

Low-certainty evidence suggests cryotherapy may slightly reduce blood loss, pain, and swelling after total knee replacement, but clinical relevance remains uncertain.

Critical Care news Pediatrics

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials

By MedXY 12/16/2025

Recent trials and meta-analyses challenge assumptions about optimal initial oxygen levels for preterm resuscitation.

news Oncology

Broad Genetic Testing Reveals Hidden Breast Cancer Risk in Women Without Family History

By MedXY 12/16/2025

The WISDOM trial found that 3.1% of women without breast cancer carried pathogenic variants in key susceptibility genes, many outside existing testing guidelines.

news OB/GYN & Women's Health

Progestagens Show Moderate Efficacy for Endometriosis Pain, But Evidence Variability Limits Clinical Certainty

By MedXY 12/16/2025

Oral progestagens reduce overall pain and dysmenorrhoea in endometriosis, but comparative benefits over other hormonal therapies remain uncertain.

Tailoring Systemic Therapy in Metastatic Hormone-Sensitive Prostate Cancer: Evidence by Disease Volume and Timing of Metastasis

Five-Year Safety of Avoiding Biopsy After Negative MRI in Prostate Cancer Pathways

Refining Prostate Cancer Risk Prediction in Men of African Ancestry: Integrating Pathogenic Variants, Polygenic Scores, and Family History

Personalizing Breast Cancer Screening: Insights from the WISDOM Trial on Risk-Based vs Annual Mammography

Prophylactic Strategies to Prevent Infection in Lower Limb Peripheral Arterial Reconstruction: Evidence and Clinical Implications

Chemoendocrine Therapy Linked to Greater Cognitive Decline in Breast Cancer Patients, Regardless of Menopausal Status

Biofeedback vs Respiratory Retraining: No Significant Difference in Inducible Laryngeal Obstruction Relief

Elevated Serotonin Release in Schizophrenia: New Insights Into Negative Symptom Pathophysiology

Combined Cardiorespiratory and Resistance Training After Stroke: Small Gains, Big Questions

Do Behavioural, Self-Management, and Service Delivery Models Improve Outcomes in Adults with Epilepsy?

Omega-3 Fatty Acids Show Limited Benefits for Diabetic Peripheral Neuropathy

Progestagens Show Promise for Pain Relief in Endometriosis, With Nuanced Efficacy Across Comparators

Rare but High-Risk: New-Onset RBBB After TAVR Strongly Linked to Pacemaker Need

Prophylactic Pacemakers After TAVR: Low Pacing Burden Raises Questions on Routine Use

PROMOTE Study Validates Algorithm for Conduction Disturbance Management After TAVR

Distinct Mechanisms Drive Early and Delayed Heart Block After TAVR: Insights from Boston Cohort Study

Cryotherapy After Total Knee Replacement: Limited Evidence for Modest Benefits

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials

Broad Genetic Testing Reveals Hidden Breast Cancer Risk in Women Without Family History

Progestagens Show Moderate Efficacy for Endometriosis Pain, But Evidence Variability Limits Clinical Certainty

Navigating Complex Decisions: Physician Strategies in Setting Stroke Care Goals for Patients with Preexisting Disability or Dementia

Influence of Parity on Cognitive Decline and Hippocampal Atrophy in Amyloid-Positive Postmenopausal Women

Long-Term Mortality, Cognition, and Quality of Life After Chronic Subdural Hematoma Surgery: A Comprehensive Review

Impact of Constitutively Active TSH Receptor Mutations on Craniofacial and Bone Morphology in Hyperthyroid Mouse Models