Medxy AI – Page 108

Persistent High Mortality in Severe Alcohol-Associated Hepatitis: Insights from a Five-Decade Meta-Analysis

By MedXY 10/09/2025

This meta-analysis reveals that short-term mortality in severe alcohol-associated hepatitis remains high, with no significant improvement over the past four decades despite advances in care, underscoring the urgent need for better therapies and prognostic strategies.

Gastroenterology Internal Medicine news

Obeticholic Acid Non-Response Signals Higher Clinical Risk in Primary Biliary Cholangitis

By MedXY 10/09/2025

In primary biliary cholangitis (PBC) patients treated with obeticholic acid (OCA), biochemical non-response strongly predicts a higher risk of clinical events including liver decompensation and mortality, underscoring the need for improved therapies.

Gastroenterology Internal Medicine news

Gut Microbiota Dysbiosis in Cirrhotic Portal Hypertension: Unraveling Microbial Contributions to Disease Progression

By MedXY 10/09/2025

Altered gut microbiota composition and metabolism exacerbate cirrhotic portal hypertension, highlighting potential microbiome-targeted therapies to mitigate disease progression.

Gastroenterology Infectious Diseases news

Optimizing Encapsulated Faecal Microbiota Transplantation for Clostridioides difficile Infection: Empirical Donor Selection and Two-Dose Regimen Enhance Cure Rates

By MedXY 10/09/2025

This study demonstrates that empirical donor exclusion combined with a two-dose capsule regimen significantly improves cure rates in Clostridioides difficile infection treated with encapsulated faecal microbiota transplantation (FMT).

Gastroenterology news Public Health

Opioid Use in Rome IV Irritable Bowel Syndrome: Prevalence and Impact on Quality of Life and Healthcare in the UK

By MedXY 10/09/2025

One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.

news Orthopedics Rheumatology

Diagnosing and Managing Methotrexate-Induced Osteopathy in Rheumatologic Practice

By MedXY 10/09/2025

Methotrexate-induced osteopathy, predominantly affecting postmenopausal women with rheumatoid or psoriatic arthritis, presents as stress fractures in the lower limbs. Early MRI or bone scintigraphy aids diagnosis, and discontinuing methotrexate shows favorable outcomes.

Diabetes & Endocrinology Gastroenterology news

Noninvasive Biomarkers Track Semaglutide Efficacy in Metabolic Dysfunction-Associated Steatohepatitis

By MedXY 10/09/2025

A phase 2b trial demonstrates that several noninvasive tests reliably reflect treatment response to semaglutide in patients with metabolic dysfunction-associated steatohepatitis, correlating with histologic improvements over 72 weeks.

Cardiology HIV/AIDS news Specialties

Early HIV Treatment and Cardiovascular Health: Insights from the START Study

By MedXY 10/09/2025

Early ART initiation in HIV-positive adults with high CD4+ counts shows no overall cardiovascular benefit, but reduced CVD events in women suggest potential sex-specific effects needing further study.

Gastroenterology news

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

By MedXY 10/09/2025

A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets beyond immunosuppression.

Emergency Medicine Pediatrics Psychiatry Radiology

Delays in Pediatric Cannabis Toxicology Testing Lead to Increased Neuroimaging in Emergency Departments

By MedXY 10/09/2025

Delayed cannabis test results in children under 6 with poisoning symptoms prolong ED visits and influence neuroimaging use. Faster toxicology screening could optimize care and reduce unnecessary scans.

General Surgery news Oncology

Minimally Invasive Surgery for Left-Sided Pancreatic Cancer: Long-Term Safety Confirmed by DIPLOMA Trial

By MedXY 10/09/2025

The DIPLOMA trial demonstrates that minimally invasive left pancreatectomy for resectable pancreatic cancer offers comparable long-term survival outcomes to open surgery, validating its oncologic safety and supporting its use in clinical practice.

Allergy & Immunology news Respiratory

Persistent Use of Green Cleaning Products Linked to Increased Asthma Risk: Implications for Clinical Practice

By MedXY 10/09/2025

Longitudinal data from the French NutriNet-Santé cohort reveal that persistent and increased use of green cleaning products is associated with a modest but significant rise in asthma symptoms, underscoring the need for cautious use and patient counseling.

Oncology Public Health

Rising Incidence of Breast Cancer Among Young Women: Trends and Implications from 1990 to 2023

By MedXY 10/09/2025

Early-onset breast cancer incidence in France has steadily increased over the past three decades, mirroring trends in other Western countries. Shifts in hormonal and lifestyle factors may contribute, highlighting the need for adapted prevention and screening strategies.

Family Medicine & Nutrition news Oncology

Decoding the Rise in Early-Onset Cancer: Implications for Primary Care and Screening Strategies

By MedXY 10/09/2025

Rising early-onset cancer incidence appears driven largely by increased diagnostic scrutiny and overdiagnosis rather than a true surge in disease, altering screening and management approaches in primary care.

Neurology news Public Health

How Poor Sleep Accelerates Brain Aging: The Role of Inflammation and What You Can Do

By MedXY 10/08/2025

New research links poor sleep quality in middle-aged and older adults to accelerated brain aging, with inflammation playing a key role. Improving sleep may help slow cognitive decline and promote brain health.

Allergy & Immunology Dermatology news

Patient-Centered Insights: Understanding Treatment Preferences in Chronic Urticaria Management

By MedXY 10/08/2025

This systematic review highlights patient and caregiver priorities in chronic urticaria treatment, emphasizing rapid symptom relief, long-term effectiveness, and safety.

Dermatology Neurology news

Transcutaneous Auricular Vagus Nerve Stimulation: A Promising New Therapy for Erythematotelangiectatic Rosacea

By MedXY 10/08/2025

A randomized trial demonstrates that 3 weeks of transcutaneous auricular vagus nerve stimulation significantly reduces facial erythema, flushing, and associated neuropsychiatric symptoms in erythematotelangiectatic rosacea, with effects persisting 24 weeks post-treatment.

Gastroenterology news Pediatrics

FDA Approves Golimumab (Simponi) for Pediatric Ulcerative Colitis: A New Therapeutic Option

By MedXY 10/08/2025

The FDA has approved golimumab (Simponi) for treating moderately to severely active ulcerative colitis in children weighing at least 15 kg, based on the PURSUIT 2 phase 3 study demonstrating significant clinical remission and safety.

Critical Care Emergency Medicine news

Exertional Heat Stroke: Critical Insights for Emergency Physicians

By MedXY 10/08/2025

Exertional heat stroke (EHS) is a life-threatening condition characterized by hyperthermia and CNS dysfunction, necessitating rapid recognition and intervention to prevent multi-organ failure and death. This article reviews its pathophysiology, diagnosis, and management essentials for clinicians.

Gastroenterology news Oncology

Menopausal Hormone Therapy and Reduced Risk of Upper Gastrointestinal Cancers: Insights From a Large Nordic Population Study

By MedXY 10/08/2025

A large Nordic study finds menopausal hormone therapy reduces the risk of esophageal and gastric cancers by up to 30%, especially with combined estrogen-progestin systemic formulations.

Persistent High Mortality in Severe Alcohol-Associated Hepatitis: Insights from a Five-Decade Meta-Analysis

Obeticholic Acid Non-Response Signals Higher Clinical Risk in Primary Biliary Cholangitis

Gut Microbiota Dysbiosis in Cirrhotic Portal Hypertension: Unraveling Microbial Contributions to Disease Progression

Optimizing Encapsulated Faecal Microbiota Transplantation for Clostridioides difficile Infection: Empirical Donor Selection and Two-Dose Regimen Enhance Cure Rates

Opioid Use in Rome IV Irritable Bowel Syndrome: Prevalence and Impact on Quality of Life and Healthcare in the UK

Diagnosing and Managing Methotrexate-Induced Osteopathy in Rheumatologic Practice

Noninvasive Biomarkers Track Semaglutide Efficacy in Metabolic Dysfunction-Associated Steatohepatitis

Early HIV Treatment and Cardiovascular Health: Insights from the START Study

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

Delays in Pediatric Cannabis Toxicology Testing Lead to Increased Neuroimaging in Emergency Departments

Minimally Invasive Surgery for Left-Sided Pancreatic Cancer: Long-Term Safety Confirmed by DIPLOMA Trial

Persistent Use of Green Cleaning Products Linked to Increased Asthma Risk: Implications for Clinical Practice

Rising Incidence of Breast Cancer Among Young Women: Trends and Implications from 1990 to 2023

Decoding the Rise in Early-Onset Cancer: Implications for Primary Care and Screening Strategies

How Poor Sleep Accelerates Brain Aging: The Role of Inflammation and What You Can Do

Patient-Centered Insights: Understanding Treatment Preferences in Chronic Urticaria Management

Transcutaneous Auricular Vagus Nerve Stimulation: A Promising New Therapy for Erythematotelangiectatic Rosacea

FDA Approves Golimumab (Simponi) for Pediatric Ulcerative Colitis: A New Therapeutic Option

Exertional Heat Stroke: Critical Insights for Emergency Physicians

Menopausal Hormone Therapy and Reduced Risk of Upper Gastrointestinal Cancers: Insights From a Large Nordic Population Study

Mapping the European Cancer Landscape: A 1.7 Million Patient Study Reveals Survival Gaps and Comorbidity Patterns

Prenatal Maternal Depression as a Critical Developmental Risk Factor: Large-Scale IPD Meta-Analysis of 76,514 Children

The Tart Cherry Revolution: A Deep Dive into the Science of Longevity, Recovery, and Restorative Sleep

Restoring Movement: How Polylaminin is Revolutionizing Spinal Cord Injury Treatment