Emerging APRIL-Targeted Therapies in IgA Nephropathy and IgA Vasculitis Nephritis: Clinical Advances with Zigakibart, Sibeprenlimab, and Telitacicept
Posted inAllergy & Immunology Clinical Updates Nephrology Specialties

Emerging APRIL-Targeted Therapies in IgA Nephropathy and IgA Vasculitis Nephritis: Clinical Advances with Zigakibart, Sibeprenlimab, and Telitacicept

Recent clinical trials of APRIL-targeted monoclonal antibodies—zigakibart, sibeprenlimab, and telitacicept—demonstrate safety and significant proteinuria reduction in IgA nephropathy and IgA vasculitis nephritis, offering promising disease-modifying therapeutic options.
Evaluating the Role of Estrogen Replacement Therapy Combined with Resistance Exercise in Older Women with Knee Osteoarthritis: Insights from a Randomised Clinical Trial
Posted inClinical Updates news Orthopedics Specialties

Evaluating the Role of Estrogen Replacement Therapy Combined with Resistance Exercise in Older Women with Knee Osteoarthritis: Insights from a Randomised Clinical Trial

This trial assessed the additive effects of low-dose transdermal estrogen replacement therapy combined with resistance exercise in women aged 65+ with knee osteoarthritis, finding no overall significant benefit but suggesting potential improvements in early-stage disease and mental health.
Silymarin in Clinical Medicine: A Decade of Therapeutic Advances and Future Disease Targets
Posted inClinical Updates Family Medicine & Nutrition Gastroenterology news Specialties

Silymarin in Clinical Medicine: A Decade of Therapeutic Advances and Future Disease Targets

Comprehensive review of recent decade research on silymarin elucidates its antioxidant, anti-inflammatory, and hepatoprotective effects, highlighting promising clinical applications in metabolic diseases, neurodegeneration, liver disorders, and inflammatory conditions, with emerging potential in oncology and dermatology.
Recent Advances in Astragalus membranaceus Research: Clinical Applications, Mechanistic Insights, and Future Therapeutic Potential
Posted inFamily Medicine & Nutrition Specialties

Recent Advances in Astragalus membranaceus Research: Clinical Applications, Mechanistic Insights, and Future Therapeutic Potential

This review synthesizes the latest PubMed-indexed evidence on Astragalus membranaceus, highlighting its immunomodulatory, renal-protective, cardiovascular, and neuroprotective effects, its synergistic potential with conventional drugs, and prospective indications for chronic kidney disease, heart failure, diabetic complications, and cancer adjunctive therapy.