Optimizing Step Counts and Intensity to Reduce Mortality Risk: Insights from UK Biobank Accelerometer Data

Both stepping intensity and daily step counts independently influence all-cause and cardiovascular mortality risk.
Mortality risk reduction exhibits dose-response relationships with combinations of stepping cadence and step volume.
7500–10 000 steps/day combined with around 100 steps/min peak cadence is associated with the lowest mortality risk.
Diverse strategies involving either higher step counts or higher stepping intensity can be effective for premature mortality prevention.