Single-cell RNA and T-/B-cell receptor sequencing of 235 bone marrow samples reveals dynamic immune landscape changes across multiple myeloma progression.
Identification of five distinct tumor microenvironment (TME) ecotypes characterized by unique immune cell compositions and functional states independent of disease stage.
Specific ecotypes correlate with clinical outcomes, tumor burden, and immunotherapy response, highlighting potential for ecotype-driven, stage-specific immunotherapies.
