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This landmark longitudinal cohort study of over 27,000 initially healthy women demonstrates that elevated plasma concentrations of high-sensitivity C-reactive protein (hsCRP), low-density lipoprotein (LDL) cholesterol, and lipoprotein(a) significantly associate with increased 30-year risk of ischaemic stroke. Notably, combined elevation of all three biomarkers potentiates stroke risk further. Conversely, these biomarkers did not predict haemorrhagic stroke risk. These findings provide robust evidence supporting comprehensive lipid and inflammatory biomarker screening for improved primary stroke prevention among women.
