Integrating Immune-Cell Transcriptomic Data with Mendelian Randomisation Reveals Novel Causal Genes for Type 2 Diabetes and Its Complications
Type 2 diabetes is a long-term metabolic disease that can damage many organs over time. Its complications, such as diabetic neuropathy, kidney disease, eye disease, and vascular problems, are a major cause of disability and reduced quality of life worldwide. Although blood glucose control remains central to management, not all complications develop in the same way, and the biological pathways behind them are still being clarified. This study used genetic evidence, immune-cell gene expression data, and advanced statistical approaches to identify genes and immune mechanisms that may causally contribute to type 2 diabetes and its complications.
