General Anesthesia May Improve 90‑Day Outcomes and Reperfusion After EVT for Large‑Vessel Ischemic Stroke: Key Takeaways from the SEGA Randomized Trial

Highlight

• The SEGA randomized trial (n=260) compared general anesthesia (GA) versus moderate sedation for endovascular therapy (EVT) in acute ischemic stroke due to large‑vessel occlusion (LVO).

• At 90 days, the ordinal modified Rankin Scale (mRS) distribution favored GA (OR 1.22; 95% credible interval [CrI] 0.79–1.87) with an 81% posterior probability of superiority.