Clinical Updates – Page 7

Evaluating the Impact of Vitamin D3, Omega-3 Fatty Acids, and Home Exercise on Vertebral Fracture Prevention in Older Adults: Insights from the DO-HEALTH Trial

By MedXY 09/20/2025

The DO-HEALTH trial found that vitamin D3 and omega-3 supplementation did not reduce vertebral fracture rates in healthy seniors, while a simple home exercise program lowered fracture incidence in women and slowed fracture progression overall, highlighting exercise’s potential role in vertebral fracture prevention.

Clinical Updates Hematology-Oncology news

Ferritin-Guided Iron Supplementation in Blood Donors: Evidence Synthesis and Clinical Implications from the FORTE Trial and Related Studies

By MedXY 09/20/2025

Iron supplementation guided by ferritin levels effectively mitigates iron deficiency and anaemia in regular blood donors, offering a practical alternative or adjunct to extending donation intervals.

Clinical Updates news Oncology

Innovative DEP-SN38 Nanoparticle Delivery Shows Promise in Advanced Solid Tumors: Safety and Preliminary Efficacy Unveiled

By MedXY 09/20/2025

This phase I study demonstrates that DEP-SN38, a dendrimer-nanoparticle conjugate of SN38, is well tolerated with minimal gastrointestinal toxicity and shows encouraging antitumor activity in heavily pretreated advanced solid tumors.

Clinical Updates news Oncology Specialties

Methylcobalamin Significantly Reduces Severe Hand-Foot Syndrome in HER2 Negative Early Breast Cancer Patients Receiving Capecitabine: Results from a Phase 3 Randomised Trial

By MedXY 09/20/2025

Oral methylcobalamin notably decreased the incidence of grade ≥2 hand-foot syndrome in patients with HER2 negative early breast cancer undergoing adjuvant capecitabine treatment, without added safety concerns, improving treatment adherence potential.

Clinical Updates news Oncology

Efficacy of Liposomal Irinotecan Plus 5-FU/LV in Previously Treated Biliary Tract Cancer: Insights from Pooled NIFTY and NALIRICC Trials

By MedXY 09/20/2025

A pooled analysis of NIFTY and NALIRICC trials demonstrates that liposomal irinotecan combined with 5-FU/leucovorin significantly improves progression-free survival and response rates in previously treated biliary tract cancer, with notable ethnic variations in toxicity profiles.

Clinical Updates news Oncology

Total Tumor Volume: A Superior Predictor of Survival and Chemotherapy Response in Colorectal Cancer Liver Metastases

By MedXY 09/20/2025

This study reveals that total tumor volume (TTV) more accurately predicts overall survival and response to induction chemotherapy than RECIST1.1 in colorectal cancer liver metastases, offering a promising tool for personalized treatment decisions.

Clinical Updates Family Medicine & Nutrition news Specialties

Single high-dose Vitamin D Protect Bone Health During Extreme Ultramarathon Running

By MedXY 09/20/2025

A single high dose of vitamin D3 before ultramarathon running reduces post-exercise bone resorption and supports bone formation, suggesting vitamin D's potential to modulate bone health via calcium and parathyroid hormone regulation during extreme endurance events.

Cardiology Clinical Updates news Specialties

Low-Dose Apixaban vs Dual Antiplatelet Therapy After Left Atrial Appendage Occlusion: Insights from the ADALA Trial

By MedXY 09/20/2025

The ADALA randomized trial compared low-dose apixaban with dual antiplatelet therapy post-LAA occlusion, demonstrating superior safety and reduced device-related thrombosis risk with low-dose anticoagulation at 3 months.

Clinical Updates news Nursing & care Orthopedics Specialties

Efficacy and Safety of Acupuncture for Chronic Low Back Pain in Older Adults: Results from a Multisite Randomized Clinical Trial

By MedXY 09/20/2025

A multisite randomized trial demonstrates that acupuncture, both standard and enhanced, significantly improves chronic low back pain-related disability in older adults compared to usual medical care, with sustained benefits and a favorable safety profile.

Clinical Updates Critical Care Emergency Medicine Neurology Specialties

Reevaluating Early Blood Pressure Targets in Acute Spinal Cord Injury: Insights from a Multicenter Randomized Trial

By MedXY 09/20/2025

A recent randomized clinical trial comparing augmented to conventional blood pressure targets in acute spinal cord injury found no improvement in 6-month neurological outcomes, challenging current practices and highlighting risks of higher blood pressure management.

Clinical Updates Internal Medicine OB/GYN & Women's Health Specialties

Evaluating Low-Dose Aspirin for Postpartum Venous Thromboembolism Prevention: Insights from the Pilot PARTUM Trial

By MedXY 09/20/2025

The pilot PARTUM trial demonstrates the feasibility of a large-scale multi-national randomized study assessing low-dose aspirin versus placebo for postpartum venous thromboembolism prevention in moderate-risk individuals, supporting further investigation.

Clinical Updates news OB/GYN & Women's Health Specialties

Certolizumab Pegol Shows Promise in Reducing Adverse Pregnancy Outcomes in High-Risk APS Patients: Insights from the IMPACT Trial

By MedXY 09/19/2025

The IMPACT trial demonstrates that adding certolizumab pegol to standard therapy reduces placenta-mediated adverse pregnancy outcomes in women with antiphospholipid syndrome and lupus anticoagulant, with favorable safety and neonatal outcomes.

Clinical Updates news OB/GYN & Women's Health Specialties

Aspirin for Delaying Preterm Birth in High-Risk Preterm Pre-eclampsia Pregnancies: Insights from a Multicenter Randomized Trial in Asia

By MedXY 09/19/2025

Early low-dose aspirin reduces early preterm birth risk and delays timing of delivery in women at high risk for preterm pre-eclampsia, with significant benefits in iatrogenic preterm births and small-for-gestational-age pregnancies.

Clinical Updates Oncology

Adjuvant Aspirin in PIK3CA-Mutated Colon Cancer: Insights from the SAKK 41/13 Randomized Trial

By MedXY 09/19/2025

The SAKK 41/13 trial provides the first prospective randomized evidence that adjuvant aspirin may improve disease-free survival in patients with resected PIK3CA-mutated stage II and III colon cancer, suggesting its potential as a safe, cost-effective adjuvant strategy.

Clinical Updates Critical Care news Specialties

Proportional-Assist Ventilation vs. Pressure-Support Ventilation: Implications for Liberation from Mechanical Ventilation

By MedXY 09/19/2025

An international trial comparing proportional-assist ventilation (PAV+) with pressure-support ventilation (PSV) showed no significant difference in time to successful liberation from mechanical ventilation among critically ill adults.

Clinical Updates news Oncology Specialties

Low-Dose Aspirin’s Impact on PI3K-Altered Localized Colorectal Cancer: New Evidence from a Randomized Controlled Trial

By MedXY 09/19/2025

This randomized trial confirms that daily low-dose aspirin significantly reduces colorectal cancer recurrence in patients with PI3K pathway mutations, highlighting a targeted adjunctive therapy option.

Clinical Updates Critical Care Specialties

Proportional-Assist Ventilation and Pressure-Support Ventilation: Comparative Impact on Mechanical Ventilation Duration in Critical Care

By MedXY 09/19/2025

A comprehensive international trial showed that proportional-assist ventilation (PAV+) does not significantly shorten the time to liberation from mechanical ventilation compared to pressure-support ventilation (PSV) in critically ill adults, with comparable safety and secondary outcomes.

Clinical Updates news Respiratory

Low-Dose Morphine in COPD: Balancing Breathlessness Relief Against Sleep-Related Respiratory Risks

By MedXY 09/19/2025

A randomized crossover trial reveals low-dose morphine in COPD does not improve sleep efficiency or breathlessness but may cause nocturnal hypoventilation, raising safety concerns despite unchanged next-day alertness.

Clinical Updates news Respiratory

Dupilumab Enhances Quality of Life and Relieves Respiratory Symptoms in COPD Patients with Type 2 Inflammation: Insights from BOREAS and NOTUS Trials

By MedXY 09/19/2025

Add-on dupilumab significantly improves health-related quality of life and respiratory symptoms in COPD patients with type 2 inflammation, according to pooled results from the BOREAS and NOTUS phase 3 trials.

Clinical Updates news Respiratory Specialties

Sustained Alterations in Glutamate Metabolism After Resistance Exercise in Older Adults With COPD and Healthy Controls

By MedXY 09/19/2025

Resistance exercise induces prolonged increases in glutamate production in older adults with COPD and healthy controls, highlighting unique metabolic adaptations that may influence pulmonary rehabilitation outcomes and muscle health.