Clinical Updates – Page 30

$Ruxolitinib Offers Durable Clinical Benefit in Steroid-Refractory Chronic Graft-Versus-Host Disease: Three-Year Final Results of the REACH3 Trial$

Ruxolitinib Offers Durable Clinical Benefit in Steroid-Refractory Chronic Graft-Versus-Host Disease: Three-Year Final Results of the REACH3 Trial

By MedXY 08/07/2025

The REACH3 study confirms ruxolitinib's superiority over best available therapy in steroid-refractory/dependent chronic GVHD, demonstrating sustained efficacy, improved failure-free survival, and a manageable long-term safety profile over three years.

Clinical Updates news Pediatrics Respiratory Specialties

Global Insights into Childhood Bronchiectasis: The First Multinational Registry Study Reveals Striking Variations and Care Gaps

By MedXY 08/07/2025

The first international paediatric bronchiectasis registry highlights significant regional differences in causes, management, and care quality, underscoring urgent needs for harmonized standards and improved multidisciplinary support.

Clinical Updates Hematology-Oncology news Specialties

Optimizing Induction Therapy in Older, Fit Patients with Newly Diagnosed Multiple Myeloma: Insights from the GEM-2017FIT Phase 3 Trial

By MedXY 08/07/2025

KRd and D-KRd regimens outperform VMP 9-Rd 9 in achieving deeper responses in older, fit, transplant-ineligible multiple myeloma patients, but toxicity remains a concern, particularly with quadruplet therapy.

Clinical Updates Hematology-Oncology news Specialties

Carfilzomib-Lenalidomide-Dexamethasone in Transplant-Ineligible Multiple Myeloma: High MRD Negativity and PFS Benefit in the EMN20 Trial

By MedXY 08/07/2025

The EMN20 phase 3 trial demonstrates that adding carfilzomib to lenalidomide-dexamethasone significantly increases MRD negativity and progression-free survival in transplant-ineligible newly diagnosed multiple myeloma, with manageable toxicity.

Clinical Updates Neurology news Specialties

Population Attributable Fractions of Established, Social-Psychological and Reproductive Risk Factors for Stroke Among Women: Evidence from UK Biobank

By MedXY 08/07/2025

This study quantifies how established, social-psychological, and reproductive factors contribute to stroke risk in women, highlighting the need for integrated prevention strategies across age groups.

Clinical Updates Oncology Specialties Urology

PARP inhibitors shine: How the TALAPRO-2 trial is changing the landscape of prostate cancer with precision medicine

By Dr.Paul 08/07/2025

Treatment for advanced prostate cancer has advanced significantly in the past decade, but metastatic castration-resistant…

Clinical Updates Oncology Specialties

No Added Survival Benefit from Adjuvant Chemotherapy in Older Women with Genomically High-Risk Hormone Receptor-Positive Breast Cancer: Results from the ASTER 70s Trial

By MedXY 08/07/2025

The ASTER 70s trial found that adding chemotherapy to hormonotherapy did not improve survival but increased toxicity in women aged 70+ with high-risk ER+/HER2- breast cancer.

Clinical Updates Neurology news Specialties

Advancing Alzheimer’s Risk Prediction: Multi-Ancestry Polygenic Risk Scores in Hispanic Populations

By MedXY 08/07/2025

Multi-ancestry polygenic risk scores significantly improve Alzheimer’s disease risk prediction in Hispanic populations compared to traditional single-ancestry models and APOE genotyping alone.

Clinical Updates news Specialties Urology

Testosterone Therapy in Middle-Aged and Older Men with Hypogonadism: Balancing Clinical Benefits and Risks

By MedXY 08/07/2025

Testosterone therapy offers modest benefits for sexual function, anemia, and bone health in older men with hypogonadism, but increases risks of venous thromboembolism, fractures, and arrhythmias. Careful patient selection and individualized risk-benefit assessment are essential.

Clinical Updates news OB/GYN & Women's Health Specialties

Seventeen-Year Follow-Up Reveals Lasting Impact of Excessive Gestational Weight Gain on Postpartum Adiposity in Black and Dominican Women

By MedXY 08/07/2025

A 17-year cohort study links excessive gestational weight gain to long-term postpartum obesity and weight retention, especially in Black and Dominican women, highlighting the need for targeted interventions during pregnancy.

Clinical Updates news Oncology Specialties

Revolutionizing Cancer Therapy: Synergistic Action of Two Natural Bacteria in Complete Tumor Eradication

By MedXY 08/06/2025

A novel bacteria-based therapy using two natural strains demonstrates complete tumor clearance in immunocompromised models, offering hope for cancer patients unsuitable for current immunotherapies.

AI Cardiology Clinical Updates news Radiology Specialties

AI-Powered Coronary Calcium Screening: Transforming Cardiovascular Risk Assessment in the Veterans Affairs Health System

By MedXY 08/06/2025

AI-CAC enables automated, accurate coronary artery calcium scoring from routine chest CTs, offering scalable, opportunistic cardiovascular risk stratification across diverse populations.

Clinical Updates news

Curcumin Mitigates Methotrexate-Induced Ovarian Damage: Insights into Antioxidant Protection via PARP-1 and P53 Modulation

By MedXY 08/06/2025

Curcumin pretreatment reduces methotrexate-induced ovarian damage in rats by regulating oxidative stress and apoptosis pathways, highlighting a potential strategy for fertility preservation in chemotherapy.

Clinical Updates news Oncology Specialties

Curcumin Shows Promise in Targeting Colorectal Cancer Stem-like Cells: Mechanistic Insights and Clinical Implications

By MedXY 08/06/2025

Curcumin, derived from turmeric, targets colorectal cancer stem-like cells, inhibits tumor growth, and promotes differentiation, offering new opportunities for cancer prevention strategies.

Clinical Updates news Orthopedics Specialties

Curcumin’s Impact on Serum Inflammatory Biomarkers in Knee Osteoarthritis: Evidence from a Systematic Review and Meta-Analysis

By MedXY 08/06/2025

A systematic review and meta-analysis found that curcumin supplementation significantly reduces serum CRP and TNF-alpha in patients with knee osteoarthritis, but not other inflammatory biomarkers.

AI Clinical Updates Neurology news Specialties

AI-Powered Smile Analysis: A Breakthrough in Parkinson’s Disease Screening

By MedXY 08/06/2025

AI analysis of smile videos demonstrates high accuracy in detecting Parkinson’s disease, offering a scalable and accessible screening solution with strong generalizability across populations.

Clinical Updates news

Vitamin D Deficiency and Accelerated Bone Loss in Mild to Moderate COPD: New Insights from the Multi-Ethnic Study of Atherosclerosis

By MedXY 08/06/2025

Mild to moderate COPD accelerates vertebral bone mineral density loss only in individuals with vitamin D deficiency, highlighting a modifiable risk factor for osteoporosis in this population.

Clinical Updates news

Intravenous Vitamin C in Malignant Neoplasms: Systematic Review Reveals Survival Benefit

By MedXY 08/06/2025

A recent meta-analysis indicates that intravenous vitamin C is associated with improved overall survival in adults with malignant neoplasms, with moderate certainty for clinical application.

Clinical Updates Family Medicine & Nutrition news Specialties

Vitamin C, the Gut Microbiome, and Mental Vitality: A New Triad for Cognitive Health in Young Adults

By MedXY 08/06/2025

A randomized controlled trial demonstrates that vitamin C supplementation enhances mental vitality in young adults with low vitamin C status, mediated by specific changes in gut microbiota and reduced inflammation.

Clinical Updates Family Medicine & Nutrition news Oncology Specialties

Vitamin C as a Cardioprotective Agent Against Doxorubicin-Induced Cardiotoxicity

By MedXY 08/06/2025

This review explores vitamin C's potential to protect the heart from doxorubicin-induced damage by reducing oxidative stress and preserving cardiac function, highlighting the need for further clinical studies.