Highlights
In a female rat model of heart failure with preserved ejection fraction (HFpEF), skeletal muscle showed evidence of mitochondrial dysfunction, reduced cardiolipin content, contractile impairment, titin abnormalities, and muscle atrophy.
Elamipretide (SS-31), a mitochondria-targeted peptide that stabilizes cardiolipin, improved whole-muscle force, enhanced single-fiber performance, and prevented further muscle wasting.
