Antiviral Prophylaxis Levels the Playing Field: Safe ICI Use in High-Viral Load HBV-HCC Patients

Highlights

1. Prospective observational data confirms that the risk of HBV reactivation is comparable between HCC patients with low (≤ 500 IU/ml) and high (> 500 IU/ml) baseline HBV DNA loads when receiving concurrent antiviral prophylaxis.

2. The study reported HBV reactivation rates of 4.5% in the low-load group and 6.1% in the high-load group, with no statistically significant difference (p = 0.29).

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